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To determine whether age‐dependent pharmacokinetic and pharmacodynamic alterations account for a more pronounced response to… Expand I Abbreviations used: ACTH, adrenocorticotropic hormone; ADCC, antibody-dependent cellular cytotoxicity; Bma .. total number of… Expand The influence of replacing the phenolic hydroxyl by the methoxy group on opioid receptor binding, analgesic and antitussive… Expand U-50,488 (trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetamide) displays analgesic actions in a variety… Expand Previous workers have noted that analgesia produced by ketamine can be antagonized by the narcotic antagonist, naloxone. In order… Expand Detailed competitive displacement curves of 3H-labeled [D-Ala2,Met5]enkephalinamide, [D-Ala2,D-Leu5]enkephalin, and… Expand Abstract Opiate receptor-ligand binding was investigated in brains of young and aged female F344 rats. A significant reduction in… Expand Drug receptors show a very high degree of ligand specificity and the opiate receptor is no exception. Thus, while all tested… Expand It was investigated whether there is an endogenous factor in the brain which binds to the opiate receptor in neural tissue… Expand Abstract: The characteristics of the interaction between dihydromorphine (DHM) and a synaptic plasma membrane (SPM) fraction from… Expand