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Dihydromorphine

Known as: Paramorfan, Morphinan-3,6-diol, 4,5-epoxy-17-methyl-, (5alpha,6alpha)-, Paramorphan 
A semisynthetic analgesic used in the study of narcotic receptors.
National Institutes of Health

Related topics

Related topics

12 relations

Broader (3)

Analgesics, OpioidNarcotic AnalgesicsNarcotics

Narrower (2)

Hydromorphone Hydrochloridedihydroheroin (3,6-diacetyldihydromorphine)
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1998
Highly Cited
1998
Pharmacokinetics and the pharmacodynamic action of midazolam in young and elderly patients undergoing tooth extraction
To determine whether age‐dependent pharmacokinetic and pharmacodynamic alterations account for a more pronounced response to… Expand
Review
1988
Review
1988
Opioid peptides and opioid receptors in cells of the immune system.
I Abbreviations used: ACTH, adrenocorticotropic hormone; ADCC, antibody-dependent cellular cytotoxicity; Bma .. total number of… Expand
Highly Cited
1988
Highly Cited
1988
Receptor binding, analgesic and antitussive potency of tramadol and other selected opioids.
The influence of replacing the phenolic hydroxyl by the methoxy group on opioid receptor binding, analgesic and antitussive… Expand
Highly Cited
1983
Highly Cited
1983
U-50,488: a selective and structurally novel non-Mu (kappa) opioid agonist.
U-50,488 (trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetamide) displays analgesic actions in a variety… Expand
Highly Cited
1982
Highly Cited
1982
Opiate receptor mediation of ketamine analgesia.
Previous workers have noted that analgesia produced by ketamine can be antagonized by the narcotic antagonist, naloxone. In order… Expand
Highly Cited
1981
Highly Cited
1981
Classification of multiple morphine and enkephalin binding sites in the central nervous system.
Detailed competitive displacement curves of 3H-labeled [D-Ala2,Met5]enkephalinamide, [D-Ala2,D-Leu5]enkephalin, and… Expand
Highly Cited
1980
Highly Cited
1980
3H-Dihydromorphine binding in brain regions of young and aged rats.
Abstract Opiate receptor-ligand binding was investigated in brains of young and aged female F344 rats. A significant reduction in… Expand
Highly Cited
1975
Highly Cited
1975
Effect of peptides and amino acids on dihydromorphine binding to the opiate receptor
  • L. Terenius
  • The Journal of pharmacy and pharmacology
  • 1975
    • Corpus ID: 8907228
Drug receptors show a very high degree of ligand specificity and the opiate receptor is no exception. Thus, while all tested… Expand
Highly Cited
1975
Highly Cited
1975
Search for an endogenous ligand for the opiate receptor.
It was investigated whether there is an endogenous factor in the brain which binds to the opiate receptor in neural tissue… Expand
Highly Cited
1973
Highly Cited
1973
Characteristics of the "receptor" for narcotic analgesics in synaptic plasma membrane fraction from rat brain.
  • L. Terenius
  • Acta pharmacologica et toxicologica
  • 1973
    • Corpus ID: 36671657
Abstract: The characteristics of the interaction between dihydromorphine (DHM) and a synaptic plasma membrane (SPM) fraction from… Expand
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