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Dihydromorphine

Known as: Paramorfan, Morphinan-3,6-diol, 4,5-epoxy-17-methyl-, (5alpha,6alpha)-, Paramorphan 
A semisynthetic analgesic used in the study of narcotic receptors.
National Institutes of Health

Related topics

Related topics

12 relations

Broader (3)

Analgesics, OpioidNarcotic AnalgesicsNarcotics

Narrower (2)

Hydromorphone Hydrochloridedihydroheroin (3,6-diacetyldihydromorphine)
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2001
2001
Contribution of dihydrocodeine and dihydromorphine to analgesia following dihydrocodeine administration in man: a PK-PD modelling analysis.
AIMS It is not clear whether the analgesic effect following dihydrocodeine (DHC) administration is due to either DHC itself or… Expand
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1998
1998
The visceral and somatic antinociceptive effects of dihydrocodeine and its metabolite, dihydromorphine. A cross-over study with extensive and quinidine-induced poor metabolizers.
AIMS Dihydrocodeine is metabolized to dihydromorphine via the isoenzyme cytochrome P450 2D6, whose activity is determined by… Expand
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Review
1988
Review
1988
Opioid peptides and opioid receptors in cells of the immune system.
I Abbreviations used: ACTH, adrenocorticotropic hormone; ADCC, antibody-dependent cellular cytotoxicity; Bma .. total number of… Expand
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Highly Cited
1988
Highly Cited
1988
Pharmacology of the allodynia in rats evoked by high dose intrathecal morphine.
Morphine sulfate in doses of 90 to 150 micrograms/3 microliters evoke a prominent behavioral syndrome characterized by 1… Expand
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Highly Cited
1988
Highly Cited
1988
Receptor binding, analgesic and antitussive potency of tramadol and other selected opioids.
The influence of replacing the phenolic hydroxyl by the methoxy group on opioid receptor binding, analgesic and antitussive… Expand
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Highly Cited
1983
Highly Cited
1983
U-50,488: a selective and structurally novel non-Mu (kappa) opioid agonist.
U-50,488 (trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetamide) displays analgesic actions in a variety… Expand
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Highly Cited
1982
Highly Cited
1982
Opiate receptor mediation of ketamine analgesia.
Previous workers have noted that analgesia produced by ketamine can be antagonized by the narcotic antagonist, naloxone. In order… Expand
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Highly Cited
1981
Highly Cited
1981
Classification of multiple morphine and enkephalin binding sites in the central nervous system.
Detailed competitive displacement curves of 3H-labeled [D-Ala2,Met5]enkephalinamide, [D-Ala2,D-Leu5]enkephalin, and… Expand
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Highly Cited
1975
Highly Cited
1975
Search for an endogenous ligand for the opiate receptor.
It was investigated whether there is an endogenous factor in the brain which binds to the opiate receptor in neural tissue… Expand
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Highly Cited
1973
Highly Cited
1973
Characteristics of the "receptor" for narcotic analgesics in synaptic plasma membrane fraction from rat brain.
  • Lars Terenius
  • Acta pharmacologica et toxicologica
  • 1973
    • Corpus ID: 36671657
Abstract: The characteristics of the interaction between dihydromorphine (DHM) and a synaptic plasma membrane (SPM) fraction from… Expand
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