Dihydromorphine

Known as: Paramorfan, Morphinan-3,6-diol, 4,5-epoxy-17-methyl-, (5alpha,6alpha)-, Paramorphan 
A semisynthetic analgesic used in the study of narcotic receptors.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1952-2017
0102019522016

Related topics

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12 relations

Broader (3)

Analgesics, OpioidNarcotic AnalgesicsNarcotics

Narrower (2)

Hydromorphone Hydrochloridedihydroheroin (3,6-diacetyldihydromorphine)
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Related mentions per year

Related mentions per year

1936-2019
19401960198020002020
Dihydromorphine
standards characteristics
Narcotics
Analgesics, Opioid
chemical synthesis
Narcotic Analgesics

Papers overview

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2006
2006
Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners.
A series of 3-O-acyl-6-O-sulfate esters of morphine, dihydromorphine, N-methylmorphinium iodide, codeine, and dihydrocodeine were… (More)
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2001
2001
Contribution of dihydrocodeine and dihydromorphine to analgesia following dihydrocodeine administration in man: a PK-PD modelling analysis.
AIMS It is not clear whether the analgesic effect following dihydrocodeine (DHC) administration is due to either DHC itself or… (More)
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1998
1998
The visceral and somatic antinociceptive effects of dihydrocodeine and its metabolite, dihydromorphine. A cross-over study with extensive and quinidine-induced poor metabolizers.
AIMS Dihydrocodeine is metabolized to dihydromorphine via the isoenzyme cytochrome P450 2D6, whose activity is determined by… (More)
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1995
1995
Simultaneous determination of dihydrocodeine and dihydromorphine in serum by gas chromatography-tandem mass spectrometry.
A sensitive and specific method was developed for the determination of dihydrocodeine and its metabolite dihydromorphine in human… (More)
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Highly Cited
1988
Highly Cited
1988
Receptor binding, analgesic and antitussive potency of tramadol and other selected opioids.
The influence of replacing the phenolic hydroxyl by the methoxy group on opioid receptor binding, analgesic and antitussive… (More)
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Highly Cited
1983
Highly Cited
1983
U-50,488: a selective and structurally novel non-Mu (kappa) opioid agonist.
U-50,488 (trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetamide) displays analgesic actions in a variety… (More)
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1981
1981
Alterations in dihydromorphine binding in cerebral hemispheres of aged male rats.
Equilibrium binding of [3H]dihydromorphine was assayed in brain regions of young and aged male F344 rats. Young rats had… (More)
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Highly Cited
1981
Highly Cited
1981
Classification of multiple morphine and enkephalin binding sites in the central nervous system.
Detailed competitive displacement curves of 3H-labeled [D-Ala2,Met5]enkephalinamide, [D-Ala2,D-Leu5]enkephalin, and… (More)
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1979
1979
Specific protection of the binding sites of D-Ala2-D-Leu5-enkephalin (delta-receptors) and dihydromorphine (mu-receptors).
Phenoxybenzamine causes a long-lasting inactivation of the opiate receptors of the mu- and delta-type in homogenates of guinea… (More)
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1975
1975
Saturable binding of dihydromorphine and naloxone to rat brain tissue in vitro.
The binding in vitro of an opiate agonist, 3H-dihydromorphine, was studied using a particulate fraction obtained from rat brain… (More)
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