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Digitoxin

Known as: Digitoksin, (3beta,5beta)-3-[(O-2,6-Dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide, Digitoxoside 
A lipid soluble cardiac glycoside that inhibits the plasma membrane sodium potassium ATPase, leading to increased intracellular sodium and calcium… 
National Institutes of Health

Related topics

Related topics

39 relations

Narrower (10)

3'''-diazomalonyldigitoxinCoramedanDigimedDigimerck
AmyloidosisAtrial FibrillationAtrial FlutterCongestive heart failure

Broader (4)

Anti-Arrhythmia AgentsCardiac GlycosidesCardiotonic AgentsEnzyme Inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
The Molecular Architecture of Human N-Acetylgalactosamine Kinase*
Galactokinase plays a key role in normal galactose metabolism by catalyzing the conversion of α-d-galactose to galactose 1… 
Highly Cited
2002
Highly Cited
2002
Enhancement of radiotherapy by oleandrin is a caspase-3 dependent process.
Highly Cited
1997
Highly Cited
1997
High-performance liquid chromatography-ionspray mass spectrometry for the specific determination of digoxin and some related cardiac glycosides in human plasma.
Highly Cited
1982
Highly Cited
1982
Isolation of plasma membrane vesicles from rabbit skeletal muscle and their use in ion transport studies.
1979
1979
Biotransformation and elimination of digoxin with normal and minimal renal function
Six subjects with normal renal function (NRF) and 6 patients with minimal renal function (MRF) on 3 times weekly hemodialysis… 
Highly Cited
1976
Highly Cited
1976
Studies on digitalis. VI. The effect of heparin on serum protein binding of digitoxin and digoxin
The aim of the present study was to investigate the nature of the previously reported changes in the serum protein binding of… 
Highly Cited
1974
Highly Cited
1974
Metabolism and excretion of digitoxin in man
The levels of digitoxin and its metabolites in the plasma, urine, and feces of 6 subjects given a single oral dose of 1 mg 3H‐dgt… 
Highly Cited
1972
Highly Cited
1972
The absorption of orally administered (12 - 3 H)digoxin in man.
1. [12α- 3 H]Digoxin and polyethylene glycol (nonabsorbable marker) dissolved in water were administered orally to five healthy… 
Highly Cited
1971
Highly Cited
1971
Regulation of lac transcription in antibiotic-treated E. coli.
Chloramphenicol stabilizes pre-existing lac mRNA, but inhibits further accumulation by allowing rapid degradation of nascent… 
Highly Cited
1970
Highly Cited
1970
The difference in sensitivity to cardiac steriods of (Na+ + K+)‐stimulated ATPase and amino acid transport in the intestinal mucosa of the rat and other species
1. The effect of various cardioactive steroids on the activity of a microsomal (Na+ + K+)‐activated ATPase from rat intestinal… 
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