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Tiacumicin B (1, also known as fidaxomicin or difimicin) is a marketed drug for the treatment of Clostridium difficile infections… Expand Oral vancomycin and oral metronidazole have several limitations with regard to their use in the treatment of Clostridium… Expand OBJECTIVE
To review the chemistry, pharmacology, microbiology, pharmacodynamics, pharmacokinetics, clinical efficacy… Expand BACKGROUND
Fidaxomicin, a macrolide antibiotic, was the first medication for the management of Clostridium difficile infections… Expand The two drugs currently recommended for the treatment of Clostridium difficile infection (CDI), namely vancomycin and… Expand Fidaxomicin, an RNA polymerase inhibitor, is being developed by Optimer and Par Pharmaceuticals as a narrow-spectrum… Expand Objective: To evaluate the efficacy and safety of fidaxomicin for the treatment of Clostridium difficile infection. Data Sources… Expand Current drug treatment of Clostridium difficile infection (CDI) focuses on metronidazole and vancomycin. Early studies showed… Expand Recent outbreaks of Clostridium difficile infection (CDI) in North America have been due to a more virulent, possibly more… Expand