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Dianhydrogalactitol
Known as:
Dulcitol diepoxide
, 1,2:5,6 dianhydrogalactitol
, 1,2,5,6-Dianhydrogalactitol
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A bifunctional hexitol derivative with potential antineoplastic activity. Dianhydrogalactitol alkylates and cross-links DNA via an epoxide group…
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National Institutes of Health
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Related topics
Related topics
14 relations
Broader (2)
Antineoplastic Agents, Alkylating
Galactitol
In Blood
NCIt Antineoplastic Agent Terminology
agonists
analogs & derivatives
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Narrower (2)
NSC-132313
dianhydro-3,4-diacetylgalactitol
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
Lipid rafts, endoplasmic reticulum and mitochondria in the antitumor action of the alkylphospholipid analog edelfosine.
C. Gajate
,
F. Mollinedo
Anti-Cancer Agents in Medicinal Chemistry
2014
Corpus ID: 4488075
The so-called alkylphospholipid analogs (APLs) constitute a family of synthetic antitumor compounds that target cell membranes…
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Highly Cited
2005
Highly Cited
2005
Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells Cultured onto Three Different Polymers In Vitro
M. Jäger
,
T. Feser
,
H. Denck
,
R. Krauspe
Annals of Biomedical Engineering
2005
Corpus ID: 34767554
In this study, the osteoinductive and cell-binding properties of three different resorbable polymers were evaluated by human…
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2003
2003
Desymmetrization of a centrosymmetric diepoxide: efficient synthesis of a key intermediate in a total synthesis of hemibrevetoxin B.
Joanne M. Holland
,
Mark L. Lewis
,
A. Nelson
Journal of Organic Chemistry
2003
Corpus ID: 45457702
The preparation of an established intermediate in a total synthesis of hemibrevetoxin B is described. The acid-catalyzed…
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Highly Cited
2001
Highly Cited
2001
Expression and Redistribution of Cellular Bad, Bax, and Bcl-xL Protein Is Associated with VCD-Induced Ovotoxicity in Rats1
Xiaoming Hu
,
P. Christian
,
I. Sipes
,
P. Hoyer
Biology of Reproduction
2001
Corpus ID: 534342
Abstract Previous studies have shown that 4-vinylcyclohexene diepoxide (VCD)-induced ovotoxicity in rats is likely caused by…
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2001
2001
First Desymmetrization of a Centrosymmetric Molecule in Natural Product Synthesis: Preparation of a Key Fragment in the Synthesis of Hemibrevetoxin B.
Joanne M. Holland
,
Mark L. Lewis
,
A. Nelson
Angewandte Chemie
2001
Corpus ID: 13989295
Exploitation of molecular symmetry can greatly improve the efficiency of syntheses. The symmetry embedded in the centrosymmetric…
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Highly Cited
1999
Highly Cited
1999
A single dose of the ovotoxicant 4-vinylcyclohexene diepoxide is protective in rat primary ovarian follicles.
S. M. Borman
,
B. Vandepol
,
S. Kao
,
K. Thompson
,
I. Sipes
,
P. Hoyer
Toxicology and Applied Pharmacology
1999
Corpus ID: 40245338
Repeated dosing of rats with the ovotoxic chemical, 4-vinylcyclohexene diepoxide (VCD), destroys primordial and primary ovarian…
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1991
1991
Studies on the reactivity of acyl glucuronides--I. Phenolic glucuronidation of isomers of diflunisal acyl glucuronide in the rat.
A. R. King
,
Ronald G. Dickinson
Biochemical Pharmacology
1991
Corpus ID: 37219270
1991
1991
Thrombin induces a biphasic 1,2-diacylglycerol production in human platelets.
Shigeru Nakashima
,
A. Suganuma
,
Akira Matsui
,
Y. Nozawa
Biochemical Journal
1991
Corpus ID: 27390295
The 1,2-diacylglycerol (DAG) mass content was measured in thrombin-stimulated human platelets. Thrombin stimulates a biphasic…
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1989
1989
Dynamics of the diradylglycerol responses of stimulated phagocytes.
R W Dougherty
,
G R Dubay
,
J. Niedel
Journal of Biological Chemistry
1989
Corpus ID: 22512218
Highly Cited
1977
Highly Cited
1977
Evaluation of single agents and combinations of chemotherapeutic agents in mouse colon carcinomas
Phd T. H. CORBETT
,
J. D. D. P. GRISWOLD
,
+14 authors
Albert Moody
Cancer
1977
Corpus ID: 43411643
Single agents and combinations of agents were tested for antitumor activity against four transplantable colon tumors in mice. The…
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