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Dexfenfluramine

Known as: Dexfenfluramine [Chemical/Ingredient], Dexfenfluraminum, (S)-N-Ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine 
The S-isomer of FENFLURAMINE. It is a serotonin agonist and is used as an anorectic. Unlike fenfluramine, it does not possess any catecholamine… 
National Institutes of Health

Related topics

Related topics

15 relations
Dexfenfluramine HydrochlorideDrug AllergyFenfluramineIn Blood

Narrower (2)

IsomerideRedux

Broader (1)

Serotonin Agonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
Serotonergic drugs and valvular heart disease
Background: The serotonin (5-HT) releasers (±)-fenfluramine and (+)-fenfluramine were withdrawn from clinical use owing to… 
Review
2009
Review
2009
Drug-induced fibrotic valvular heart disease
Highly Cited
2002
Highly Cited
2002
Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension
Primary pulmonary hypertension is a progressive and often fatal disorder in humans that results from an increase in pulmonary… 
Review
2002
Review
2002
Serotonin releasing agents Neurochemical, therapeutic and adverse effects
Highly Cited
2000
Highly Cited
2000
Valvular abnormalities and cardiovascular status following exposure to dexfenfluramine or phentermine/fenfluramine.
CONTEXT Fenfluramine and dexfenfluramine were voluntarily withdrawn from the market in September 1997 because of reports of an… 
Highly Cited
1998
Highly Cited
1998
An assessment of heart-valve abnormalities in obese patients taking dexfenfluramine, sustained-release dexfenfluramine, or placebo. Sustained-Release Dexfenfluramine Study Group.
BACKGROUND The appetite-suppressant drug fenfluramine, usually given in combination with phentermine, has been reported to be… 
Highly Cited
1998
Highly Cited
1998
A comparison of the effects on central 5‐HT function of sibutramine hydrochloride and other weight‐modifying agents
1 Effects on 5‐HT function of sibutramine and its active metabolites, BTS 54 354 and BTS 54 505, were compared with fluoxetine… 
Highly Cited
1997
Highly Cited
1997
Carrier‐dependent and Ca2+‐dependent 5‐HT and dopamine release induced by (+)‐amphetamine, 3,4‐methylendioxy‐methamphetamine, p‐chloroamphetamine and (+)‐fenfluramine
1 The mechanism underlying 5‐hydroxytryptamine (5‐HT) and/or dopamine release induced by (+)‐amphetamine ((+)‐Amph), 3,4… 
Highly Cited
1992
Highly Cited
1992
The substituted amphetamines 3,4-methylenedioxymethamphetamine, methamphetamine, p-chloroamphetamine and fenfluramine induce 5-hydroxytryptamine release via a common mechanism blocked by fluoxetine…
Highly Cited
1989
Highly Cited
1989
INTERNATIONAL TRIAL OF LONG-TERM DEXFENFLURAMINE IN OBESITY
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