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Deimmunization

Known as: De-immunization 
A laboratory procedure where the gene encoding a therapeutic recombinant protein is manipulated to minimize the immunogenicity of the protein. This… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Validation of a de‐immunization strategy for monoclonal antibodies using cynomolgus macaque as a surrogate for human
The immunogenicity of biotherapeutics presents a major challenge during the clinical development of new protein drugs including… 
Review
2017
Review
2017
Addressing the Immunogenicity of the Cargo and of the Targeting Antibodies with a Focus on Deimmunized Bacterial Toxins and on Antibody-Targeted Human Effector Proteins
Third-generation immunotoxins are composed of a human, or humanized, targeting moiety, usually a monoclonal antibody or an… 
2017
2017
Therapeutic protein deimmunization by T‐cell epitope removal: antigen‐specific immune responses in vitro and in vivo
Hirudin III is an effective anti‐coagulant; however, in 40% of treated patients, a high‐titer of anti‐Hirudin III IgG antibodies… 
2016
2016
Dual B- and T-cell de-immunization of recombinant immunotoxin targeting mesothelin with high cytotoxic activity
Recombinant immunotoxins (RITs) are genetically engineered proteins being developed to treat cancer. They are composed of an Fv… 
2016
2016
Deimmunization for gene therapy: host matching of synthetic zinc finger constructs enables long-term mutant Huntingtin repression in mice
Synthetic zinc finger (ZF) proteins can be targeted to desired DNA sequences and are useful tools for gene therapy. We recently… 
2015
2015
Protein deimmunization via structure‐based design enables efficient epitope deletion at high mutational loads
Anti‐drug immune responses are a unique risk factor for biotherapeutics, and undesired immunogenicity can alter pharmacokinetics… 
2013
2013
In silico high throughput pre-clinical determination of monoclonal antibody immunogenicity (P3391)
One of the great surprises of the biologics revolution has been the discovery that recombinant human proteins, including… 
2012
2012
Anti-C2 monoclonal antibody 46 CHAPTER III CONSTRUCTION OF EXPRESSION VECTORS WITH HUMANIZED ANTI-C2 VARIABLE REGIONS USING DEIMMUNIZATION AND LOGICAL APPROACH METHODS
  • 2012
  • Corpus ID: 73567670
2010
2010
Deimmunization of HLA-DR Epitopes in the C2 Domain of Human FVIII (144.29)
To reduce immunogenicity of therapeutic proteins, recombinant proteins can be modified to lower HLA binding of epitopes, a… 
Highly Cited
2009
Highly Cited
2009
Deimmunization of monoclonal antibodies.
Immunogenicity is a major limitation to therapy with certain monoclonal antibodies and proteins. A major driver for… 
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