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Trans-chalcone: a novel small molecule inhibitor of mammalian alpha-amylase
- M. Najafian, A. Ebrahim-Habibi, Nastaran Hezareh, P. Yaghmaei, K. Parivar, B. Larijani
- Biology, ChemistryMolecular Biology Reports
- 1 March 2011
Trans-chalcone (1,3-diphenyl-2-propen-1-one), a biphenolic core structure of flavonoids precursor, could be used to design effective inhibitors of alpha-amylase.
Neuroprotective effects of metformin against Aβ-mediated inhibition of long-term potentiation in rats fed a high-fat diet
Core structure of flavonoids precursor as an antihyperglycemic and antihyperlipidemic agent: an in vivo study in rats.
- M. Najafian, A. Ebrahim-Habibi, P. Yaghmaei, K. Parivar, B. Larijani
- Biology, MedicineActa biochimica Polonica
- 9 November 2010
Trans-chalcone was observed to have a weight loss-inductive effect, alongside with a reduction in food intake, which is suggestive of a therapeutic potential of this compound in overweight and obese patients.
Effect of polyamines on the structure, thermal stability and 2,2,2-trifluoroethanol-induced aggregation of alpha-chymotrypsin.
Mutation screening of VHL gene in a family with malignant bilateral pheochromocytoma: from isolated familial pheochromocytoma to von Hippel-Lindau disease
The presence of a single nucleotide mutation in exon 3 of VHL gene c499 C>T causing substitution of Arginine by Tryptophan at position 167 (R 167 W) was detected in a family with bilateral malignant pheochromocytoma, finally diagnosed as von Hipple-Lindau disease according to retinal angioma and V HL gene mutation.
Citral as a potential antihyperlipidemic medicine in diabetes: a study on streptozotocin-induced diabetic rats
Citral was found to be a moderate inhibitor of mammalian alpha-amylase, with an IC50 of 120 μM, and caused also a decrease of alpha-AMylase levels in vivo, and moderate lowering of postprandial glucose, alongside with normalization of blood lipid profile was observed in diabetic rats upon treatment with the compound.
Role of electrostatic interactions in 2,2,2-trifluoroethanol-induced structural changes and aggregation of alpha-chymotrypsin.
Acarbose versus trans-chalcone: comparing the effect of two glycosidase inhibitors on obese mice.
- F. Jalalvand, M. Amoli, P. Yaghmaei, M. Kimiagar, A. Ebrahim-Habibi
- Medicine, BiologyArchives of endocrinology and metabolism
- 1 June 2015
The tested compounds were able to affect lipid accumulation in tissues and influence adipokines, which may result in an enhanced state with regard to inflammation and oxidative stress.
Silymarin effect on amyloid-β plaque accumulation and gene expression of APP in an Alzheimer’s disease rat model
- P. Yaghmaei, Katia Azarfar, M. Dezfulian, A. Ebrahim-Habibi
- Biology, MedicineDARU Journal of Pharmaceutical Sciences
- 24 January 2014
It is suggested that the beneficial effect of sylimarin in the AD model is related to its capacity to disaggregate amyloid plaques and to suppress APP expression.