Death Domain

Known as: Death Domains 
The death domain is a protein region, approximately 80 amino acids long, that is required for transmission of the cytotoxic signal of apoptosis and… (More)
National Institutes of Health

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Highly Cited
2008
Highly Cited
2008
Necroptosis is a cellular mechanism of necrotic cell death induced by apoptotic stimuli in the form of death domain receptor… (More)
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Highly Cited
2001
Highly Cited
2001
Members of the tumour-necrosis factor receptor (TNFR) family that contain an intracellular death domain initiate signalling by… (More)
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Review
1998
Review
1998
An expanding family of BCL-2 related proteins share homology, clustered within four conserved regions, namely BCL-2 homology (BH1… (More)
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Review
1998
Review
1998
Bcl-2-related proteins have come to occupy a prominent position in the realm of programmed cell death. Members of this fast… (More)
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Highly Cited
1997
Highly Cited
1997
TRAIL, also called Apo2L, is a cytotoxic protein that induces apoptosis of many transformed cell lines but not of normal tissues… (More)
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Highly Cited
1997
Highly Cited
1997
A fourth member of the emerging TRAIL receptor family, TRAIL-R4, has been cloned and characterized. TRAIL-R4 encodes a 386-amino… (More)
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Highly Cited
1997
Highly Cited
1997
Apo2 ligand (Apo2L [1], also called TRAIL for tumor necrosis factor (TNF)-related apoptosis-inducing ligand [2]) belongs to the… (More)
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Highly Cited
1996
Highly Cited
1996
The BCL-2 family of proteins consists of both antagonists (e.g., BCL-2) and agonists (e.g., BAX) that regulate apoptosis and… (More)
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Highly Cited
1995
Highly Cited
1995
Ligation of the extracellular domain of the cell surface receptor Fas/APO-1 (CD95) elicits a characteristic programmed death… (More)
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Highly Cited
1993
Highly Cited
1993
Deletion mutagenesis of the intracellular region of the 55 kd TNF receptor (TNF-R1) identified an approximately 80 amino acid… (More)
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