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Daptomycin

Known as: N-Decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon1-lactone, N-decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine-epsilon1-lactone, Daptomycin [Chemical/Ingredient] 
A semi-synthetic cyclic lipopeptide antibiotic isolated form the bacterium Streptomyces roseosporus with broad-spectrum antibiotic activity against… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
ABSTRACT In the setting of catheter-related bloodstream infections, intraluminal antibiotic lock therapy could be useful for the… Expand
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Alternative therapies for Staphylococcus aureus bacteremia and endocarditis are needed. METHODS We randomly assigned… Expand
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Highly Cited
2006
Highly Cited
2006
ABSTRACT We present here findings of a strong positive correlation between reduced daptomycin susceptibility and vancomycin… Expand
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Highly Cited
2006
Highly Cited
2006
ABSTRACT Daptomycin is a lipopeptide antibiotic with potent activity against gram-positive bacteria. Complete-genome comparisons… Expand
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Review
2005
Review
2005
Infections caused by drug-resistant pathogens are on the rise. Daptomycin, a cyclic lipopeptide with activity against most Gram… Expand
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Highly Cited
2005
Highly Cited
2005
The lipopeptide daptomycin has been approved for use in skin and skin-structure infections but has failed to meet statistical… Expand
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Highly Cited
2004
Highly Cited
2004
Daptomycin is the first available agent from a new class of antibiotics, the cyclic lipopeptides, that has activity against a… Expand
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Highly Cited
2004
Highly Cited
2004
ABSTRACT Daptomycin is a lipopeptide antibiotic with activity against a wide range of gram-positive bacteria. We used the… Expand
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Review
2004
Review
2004
Daptomycin is a novel cyclic lipopeptide antibiotic that provides rapid bactericidal activity against gram-positive pathogens in… Expand
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Highly Cited
2003
Highly Cited
2003
ABSTRACT The objective of this study was to further elucidate the role of membrane potential in the mechanism of action of… Expand
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