Daptomycin

Known as: N-Decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon1-lactone, N-decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine-epsilon1-lactone, Daptomycin [Chemical/Ingredient] 
A semi-synthetic cyclic lipopeptide antibiotic isolated form the bacterium Streptomyces roseosporus with broad-spectrum antibiotic activity against… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1966-2018
010020019662018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
BACKGROUND Alternative therapies for Staphylococcus aureus bacteremia and endocarditis are needed. METHODS We randomly assigned… (More)
  • table 1
  • table 1
  • table 2
  • figure 1
  • table 3
Is this relevant?
Highly Cited
2006
Highly Cited
2006
We present here findings of a strong positive correlation between reduced daptomycin susceptibility and vancomycin resistance in… (More)
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Daptomycin is a lipopeptide antibiotic with potent activity against gram-positive bacteria. Complete-genome comparisons of… (More)
Is this relevant?
Highly Cited
2005
Highly Cited
2005
We describe a patient who developed daptomycin-resistant, methicillin-resistant Staphylococcus aureus (MRSA) during an episode of… (More)
  • table 1
Is this relevant?
Highly Cited
2005
Highly Cited
2005
The lipopeptide daptomycin has been approved for use in skin and skin-structure infections but has failed to meet statistical… (More)
  • table 1
  • figure 1
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Daptomycin is a lipopeptide antibiotic with activity against a wide range of gram-positive bacteria. We used the neutropenic… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 2
  • table 1
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Daptomycin is the first available agent from a new class of antibiotics, the cyclic lipopeptides, that has activity against a… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
We evaluated the impact of high (9.5 log10 CFU/g) and moderate (5.5 log10 CFU/g) inocula of methicillin-susceptible and… (More)
  • table 1
  • table 2
  • figure 1
  • figure 2
  • table 3
Is this relevant?
Highly Cited
2003
Highly Cited
2003
The objective of this study was to further elucidate the role of membrane potential in the mechanism of action of daptomycin, a… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2001
Highly Cited
2001
We studied the in vitro emergence of resistance to daptomycin using three methods: spontaneous resistance incidence, serial… (More)
  • figure 1
  • table 1
  • table 2
  • table 3
Is this relevant?