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LY-146032

Known as: LY 146032, LY146032 
National Institutes of Health

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Broader (1)

Daptomycin

Papers overview

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1990
1990
Experimental studies on nephrotoxicity and pharmacokinetics of LY 146032 (daptomycin) in rats.
The nephrotoxicity and pharmacokinetics of LY 146032 (daptomycin) were studied in an experimental rat model. Nephrotoxicity was… 
Highly Cited
1989
Highly Cited
1989
Comparative evaluation of daptomycin (LY146032) and vancomycin in the treatment of experimental methicillin-resistant Staphylococcus aureus osteomyelitis in rabbits
A rabbit model for methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis was used to compare treatment with daptomycin… 
1989
1989
Treatment of chronic experimentalStaphylococcus aureus osteomyelitis with LY146032 and vancomycin
LY146032 and vancomycin were compared as therapeutic agents in the treatment of chronicStaphylococcus aureus osteomyelitis in the… 
1989
1989
Ex vivo study of serum bactericidal titers and killing rates of daptomycin (LY146032) combined or not combined with amikacin compared with those of vancomycin.
Twelve volunteers, in two groups of six, received daptomycin at a dose of 1 or 2 mg/kg. In addition, they received in a randomly… 
1988
1988
In vitro selection of bacteria resistant to LY146032, a new cyclic lipopeptide
Isolates of Streptococcus pneumoniae, Enterococcus faecalis, Enterococcus faecium, and coagulase-positive and -negative… 
1988
1988
In vitro activities of daptomycin (LY146032) and paldimycin (U-70,138F) against anaerobic gram-positive bacteria
The in vitro activities of daptomycin (LY146032), paldimycin (U-70,138F), vancomycin, and penicillin G against 344 clinical… 
1987
1987
Comparative in-vitro activity of LY146032 a new peptolide, with vancomycin and eight other agents against gram-positive organisms.
The in-vitro activity of LY146032, a new biosynthetic peptolide antibiotic, was compared with vancomycin and eight other… 
1987
1987
Activity of LY146032 against Enterococci with and without high-level aminoglycoside resistance, including two penicillinase-producing strains
We tested the activity of LY146032 (LY) against 57 strains of enterococci collected from Chile, Thailand, and the United States… 
1987
1987
Activity of LY146032 in vitro and in experimental enterococcal pyelonephritis
The efficacy of LY146032 (LY), a new lipopeptide antibiotic, was compared with that of vancomycin, ciprofloxacin, ceftriaxone… 
1987
1987
In vitro activity of a new cyclic lipopeptide antibiotic, LY146032, against gram-positive clinical bacteria
The in vitro activity of LY146032, a novel cyclic lipopeptide antibiotic, was tested against different gram-positive clinical… 
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