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Dapper Homolog 2

Known as: DACT2, Dapper Antagonist of Catenin 2 
Dapper homolog 2 (774 aa, ~83 kDa) is encoded by the human DACT2 gene. This protein is involved in the inhibition of signal transduction.
National Institutes of Health

Related topics

Related topics

4 relations
DACT2 geneSignal TransductionSignaling Pathway GeneTGF-Beta Receptor Signaling Pathway

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Delamination of neural crest cells requires transient and reversible Wnt inhibition mediated by Dact1/2
Delamination of neural crest (NC) cells is a bona fide physiological model of epithelial-to-mesenchymal transition (EMT), a… 
2016
2016
Methylation of DACT2 accelerates esophageal cancer development by activating Wnt signaling
Esophageal cancer is one of the most common malignancies worldwide. DACT2 is frequently methylated in human lung, hepatic… 
2016
2016
DACT2 silencing by promoter CpG methylation disrupts its regulation of epithelial-to-mesenchymal transition and cytoskeleton reorganization in breast cancer cells
Wnt signaling plays an important role in breast carcinogenesis. DAPPER2 (DACT2) functions as an inhibitor of canonical Wnt… 
Review
2014
Review
2014
Wnt signaling pathway in non-small cell lung cancer.
  • D. Stewart
  • Journal of the National Cancer Institute
  • 2014
  • Corpus ID: 14298118
Wnt/β-catenin alterations are prominent in human malignancies. In non-small cell lung cancer (NSCLC), β-catenin and APC mutations… 
2014
2014
DACT2 is frequently methylated in human gastric cancer and methylation of DACT2 activated Wnt signaling.
Dapper, Dishevelled-associated antagonist of β-catenin (DACT), is a key regulator of Wnt signaling pathway. The purpose of this… 
2014
2014
Methylation of DACT2 Promotes Papillary Thyroid Cancer Metastasis by Activating Wnt Signaling
Thyroid cancer is the most common endocrine malignant disease and the incidence is increasing. DACT2 was found frequently… 
Highly Cited
2013
Highly Cited
2013
Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer
Dapper, Dishevelled‐associated antagonist of β‐catenin (DACT), is involved in Xenopus embryonic development. Human DACT2 is… 
2013
2013
DACT2 Is a Candidate Tumor Suppressor and Prognostic Marker in Esophageal Squamous Cell Carcinoma
In animals ranging from fish to mice, the function of DACT2 as a negative regulator of the TGF-β/Nodal signal pathway is… 
Highly Cited
2008
Highly Cited
2008
Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis.
Systemic sclerosis (SSc) is a complex human disorder characterized by progressive skin fibrosis. To better understand the… 
Review
2005
Review
2005
Frodo proteins: modulators of Wnt signaling in vertebrate development.
  • B. BrottS. Sokol
  • Differentiation; research in biological diversity
  • 2005
  • Corpus ID: 10540055
The Frodo/dapper (Frd) proteins are recently discovered signaling adaptors, which functionally and physically interact with Wnt… 
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