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Dapper Homolog 2

Known as: DACT2, Dapper Antagonist of Catenin 2 
Dapper homolog 2 (774 aa, ~83 kDa) is encoded by the human DACT2 gene. This protein is involved in the inhibition of signal transduction.
National Institutes of Health

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Related topics

4 relations
DACT2 geneSignal TransductionSignaling Pathway GeneTGF-Beta Receptor Signaling Pathway

Papers overview

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2018
2018
The new 6q27 tumor suppressor DACT2, frequently silenced by CpG methylation, sensitizes nasopharyngeal cancer cells to paclitaxel and 5-FU toxicity via β-catenin/Cdc25c signaling and G2/M arrest
BackgroundNasopharyngeal carcinoma (NPC) is prevalent in South China, including Hong Kong and Southeast Asia, constantly… Expand
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2016
2016
Delamination of neural crest cells requires transient and reversible Wnt inhibition mediated by Dact1/2.
Delamination of neural crest (NC) cells is a bona fide physiological model of epithelial-to-mesenchymal transition (EMT), a… Expand
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2015
2015
Pilomyxoid Astrocytoma (PMA) Shows Significant Differences in Gene Expression vs. Pilocytic Astrocytoma (PA) and Variable Tendency Toward Maturation to PA.
Pilomyxoid astrocytomas (PMAs) manifest a more aggressive clinical course than pilocytic astrocytomas (PAs). Development of… Expand
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2015
2015
Expression and epigenetic regulation of DACT1 and DACT2 in oral squamous cell carcinoma.
BACKGROUND DACT genes regulates Wnt as well TGF-β pathway, and were already associated with hepatocellular and lung cancer… Expand
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Review
2014
Review
2014
Wnt signaling pathway in non-small cell lung cancer.
  • David J Stewart
  • Journal of the National Cancer Institute
  • 2014
    • Corpus ID: 14298118
Wnt/β-catenin alterations are prominent in human malignancies. In non-small cell lung cancer (NSCLC), β-catenin and APC mutations… Expand
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2014
2014
DACT2 is frequently methylated in human gastric cancer and methylation of DACT2 activated Wnt signaling.
Dapper, Dishevelled-associated antagonist of β-catenin (DACT), is a key regulator of Wnt signaling pathway. The purpose of this… Expand
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2013
2013
Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer.
Dapper, Dishevelled-associated antagonist of β-catenin (DACT), is involved in Xenopus embryonic development. Human DACT2 is… Expand
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2013
2013
Dact2 Represses PITX2 Transcriptional Activation and Cell Proliferation through Wnt/beta-Catenin Signaling during Odontogenesis
Dact proteins belong to the Dapper/Frodo protein family and function as cytoplasmic attenuators in Wnt and TGFβ signaling… Expand
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Highly Cited
2008
Highly Cited
2008
Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis.
Systemic sclerosis (SSc) is a complex human disorder characterized by progressive skin fibrosis. To better understand the… Expand
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Review
2005
Review
2005
Frodo proteins: modulators of Wnt signaling in vertebrate development.
The Frodo/dapper (Frd) proteins are recently discovered signaling adaptors, which functionally and physically interact with Wnt… Expand
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