FAQ

Dapper Homolog 2

Known as: DACT2, Dapper Antagonist of Catenin 2 
Dapper homolog 2 (774 aa, ~83 kDa) is encoded by the human DACT2 gene. This protein is involved in the inhibition of signal transduction.
National Institutes of Health

Topic mentions per year

Topic mentions per year

2005-2017
02420052017

Related topics

Related topics

4 relations
DACT2 geneSignal TransductionSignaling Pathway GeneTGF-Beta Receptor Signaling Pathway

Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
Dapper Homolog 2
Signal Transduction
TGF-Beta Receptor Signaling Pathway
DACT2 gene
Signaling Pathway Gene

Papers overview

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2016
2016
Prognostic significance of the methylation of Wnt pathway antagonists—CXXC4, DACT2, and the inhibitors of sonic hedgehog signaling—ZIC1, ZIC4, and HHIP in head and neck squamous cell carcinomas
Aberrations in Wnt and Shh signaling pathways are related to the pathogenesis of head and neck carcinomas, and their activation… (More)
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2015
2015
Characterization of the nasopharyngeal carcinoma methylome identifies aberrant disruption of key signaling pathways and methylated tumor suppressor genes.
AIMS Nasopharyngeal carcinoma (NPC) is a common tumor consistently associated with Epstein-Barr virus infection and prevalent in… (More)
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2015
2015
Expression and epigenetic regulation of DACT1 and DACT2 in oral squamous cell carcinoma.
BACKGROUND DACT genes regulates Wnt as well TGF-β pathway, and were already associated with hepatocellular and lung cancer… (More)
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2015
2015
DACT2 is a functional tumor suppressor through inhibiting Wnt/β-catenin pathway and associated with poor survival in colon cancer
Dapper homolog (DACT) 2 is one of the Dact gene family members, which are important modulators of Wnt signaling pathway. We aim… (More)
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2014
2014
DACT2 is frequently methylated in human gastric cancer and methylation of DACT2 activated Wnt signaling.
Dapper, Dishevelled-associated antagonist of β-catenin (DACT), is a key regulator of Wnt signaling pathway. The purpose of this… (More)
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2013
2013
Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer.
Dapper, Dishevelled-associated antagonist of β-catenin (DACT), is involved in Xenopus embryonic development. Human DACT2 is… (More)
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2013
2013
DACT2 is a candidate tumor suppressor and prognostic marker in esophageal squamous cell carcinoma.
In animals ranging from fish to mice, the function of DACT2 as a negative regulator of the TGF-β/Nodal signal pathway is… (More)
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2013
2013
Epigenetic regulation of the Wnt signaling inhibitor DACT2 in human hepatocellular carcinoma.
DACT2 (Dapper, Dishevelled-associated antagonist of β-catenin homolog 2) is a member of the DACT family involved in the… (More)
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2011
2011
Linkage and association analysis of hyperthyrotropinaemia in an Alpine population reveal two novel loci on chromosomes 3q28-29 and 6q26-27.
BACKGROUND Thyroid hormones have important roles in growth, development and control of metabolism, and their dysregulation can… (More)
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2008
2008
Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis.
Systemic sclerosis (SSc) is a complex human disorder characterized by progressive skin fibrosis. To better understand the… (More)
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