Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
- D. Klionsky, K. Abdelmohsen, S. Zughaier
- BiologyAutophagy
- 18 April 2012
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms.
Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer
The first metagenomic profiling study of CRC faecal microbiomes is presented to discover and validate microbial biomarkers in ethnically different cohorts, and to independently validate selected biomarkers using an affordable clinically relevant technology.
Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma
- C. Pickering, Jane H. Zhou, M. Frederick
- Medicine, BiologyClinical Cancer Research
- 10 October 2014
The mutational spectrum of cSCC is similar to that of head and neck squamous cell carcinoma and dominated by tumor-suppressor genes, which improve the foundation for understanding this disease and should aid in identifying and treating aggressive cS CC.
Molecular Characterization of the Fecal Microbiota in Patients with Nonalcoholic Steatohepatitis – A Longitudinal Study
NASH patients have fecal dysbiosis, and changes in microbiota correlate with improvement in hepatic steatosis, and bacterial biodiversity did not differ between NASH patients and controls, and did not change with probiotic treatment.
International network of cancer genome projects
- T. Hudson, W. Anderson, B. Wainwright
- EngineeringNature
- 22 March 2010
Systematic studies of more than 25,000 cancer genomes will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.
Animal models of non‐alcoholic fatty liver disease: current perspectives and recent advances
- J. Lau, Xiang Zhang, Jun Yu
- BiologyJournal of Pathology
- 22 November 2016
Although current animal models provide critical guidance in understanding specific stages of NAFLD pathogenesis and progression, further research is necessary to develop more accurate models that better mimic the disease spectrum, in order to provide both increased mechanistic understanding and identification/testing of novel therapeutic approaches.
Gut microbiota in colorectal cancer: mechanisms of action and clinical applications
The role of microorganisms in colorectal carcinogenesis, and the potential clinical translation of the gut microbiota as a biomarker for CRC diagnosis and prognosis are described, and as an approach for disease prevention and to improve therapy are described.
Mucosal microbiome dysbiosis in gastric carcinogenesis
- O. Coker, Zhenwei Dai, Jun Yu
- Medicine, BiologyGut
- 1 August 2017
Differences in bacterial interactions across stages of gastric carcinogenesis are identified and significant enrichments and network centralities suggest potentially important roles of P. pneumosintes, S. exigua, P. stomatis, D. micra and S. anginosus in GC progression.
WNT5A Exhibits Tumor-Suppressive Activity through Antagonizing the Wnt/β-Catenin Signaling, and Is Frequently Methylated in Colorectal Cancer
WNT5A is frequently inactivated in CRC by tumor-specific methylation, and thus, is a potential biomarker that could act as a tumor suppressor for CRC by antagonizing the Wnt/β-catenin signaling.
Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer.
It is demonstrated that H19-derived miR-675, through downregulation of its target RB, regulates the CRC development and thus may serve as a potential target for CRC therapy.
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