Dacarbazine

Known as: Dakarbazin, Dacarbazinum, Dacarbazine - DTIC 
A drug that is used to treat Hodgkin lymphoma and malignant melanoma and is being studied in the treatment of other types of cancer. It attaches to… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1939-2018
010020030019392017

Papers overview

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Highly Cited
2015
Highly Cited
2015
BACKGROUND Nivolumab was associated with higher rates of objective response than chemotherapy in a phase 3 study involving… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Dabrafenib, an inhibitor of mutated BRAF, has clinical activity with a manageable safety profile in studies of phase 1… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Activating mutations in serine-threonine protein kinase B-RAF (BRAF) are found in 50% of patients with advanced… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Ipilimumab monotherapy (at a dose of 3 mg per kilogram of body weight), as compared with glycoprotein 100, improved… (More)
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Highly Cited
2006
Highly Cited
2006
PURPOSE Chemotherapy resistance in melanoma has been linked to antiapoptotic effects mediated by Bcl-2 protein. We evaluated… (More)
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Highly Cited
2000
Highly Cited
2000
PURPOSE To compare, in 305 patients with advanced metastatic melanoma, temozolomide and dacarbazine (DTIC) in terms of overall… (More)
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Highly Cited
1999
Highly Cited
1999
PURPOSE Several single-institution phase II trials have reported that the Dartmouth regimen (dacarbazine, cisplatin, carmustine… (More)
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Highly Cited
1998
Highly Cited
1998
PURPOSE To investigate the response rate, time to treatment failure (TTF), overall survival, and toxicity in patients with… (More)
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Highly Cited
1994
Highly Cited
1994
Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is inhibited by a new series of pyridinyl… (More)
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Highly Cited
1978
Highly Cited
1978
A human leukemic cell line (designated HL-60) has recently been established from the peripheral blood leukocytes of a patient… (More)
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