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The balance between excitatory and inhibitory synapses is crucial for normal brain function. Wnt proteins stimulate synapse… Expand Axon guidance and target-derived signals control axonal behavior by regulating the cytoskeleton through poorly defined mechanisms… Expand In Drosophila, activation of Jun N-terminal Kinase (JNK) mediated by Frizzled and Dishevelled leads to signaling linked to planar… Expand Wnt proteins regulate the formation of central synapses by stimulating synaptic assembly, but their role at the vertebrate… Expand Proper dialogue between presynaptic neurons and their targets is essential for correct synaptic assembly and function. At central… Expand Approximately 20% of familial amyotrophic lateral sclerosis (FALS) arises from germ-line mutations in the superoxide dismutase-1… Expand Previously we have cloned the human Frizzled 1 (HFz1) and shown that it transmits the Wnt-3a-induced canonical pathway. We also… Expand Members of the Wnt family of signaling molecules are important in cell specification and epithelial-mesenchymal interactions, and… Expand Recent improvements in the clinical management of acute myocardial infarction (MI) have resulted in a dramatic decrease in… Expand One aspect of the function of the β-arrestins is to serve as scaffold or adapter molecules coupling G-protein coupled receptors… Expand