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Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus
- J. Malberg, A. Eisch, E. Nestler, R. Duman
- Biology, PsychologyThe Journal of Neuroscience
- 15 December 2000
Investigation of the effect of antidepressants on hippocampal neurogenesis in the adult rat using the thymidine analog bromodeoxyuridine (BrdU) as a marker for dividing cells demonstrates that chronic antidepressant treatment significantly increases the number of BrdU-labeled cells in the dentate gyrus and hilus of the hippocampus.
The molecular neurobiology of depression
Recent studies combining behavioural, molecular and electrophysiological techniques reveal that certain aspects of depression result from maladaptive stress-induced neuroplastic changes in specific neural circuits and show that understanding the mechanisms of resilience to stress offers a crucial new dimension for the development of fundamentally novel antidepressant treatments.
Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions
Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress
It is shown that viral-mediated, mesolimbic dopamine pathway–specific knockdown of brain-derived neurotrophic factor is required for the development of experience-dependent social aversion in mice experiencing repeated aggression.
Molecular basis of long-term plasticity underlying addiction
- E. Nestler
- BiologyNature Reviews Neuroscience
In Box 1, two parts of the text read 'histone acetylase activity' should have read ' historical acetylation'.
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
- Nadia M. Tsankova, O. Berton, W. Renthal, Arvind Kumar, Rachel L Neve, E. Nestler
- Biology, PsychologyNature Neuroscience
- 1 April 2006
An important role for histone remodeling in the pathophysiology and treatment of depression is underscored and the therapeutic potential for hist one methylation and deacetylation inhibitors in depression is highlighted.
Neural mechanisms of addiction: the role of reward-related learning and memory.
Progress in identifying candidate mechanisms of addiction is reviewed, including molecular and cellular mechanisms that underlie long-term associative memories in several forebrain circuits (involving the ventral and dorsal striatum and prefrontal cortex) that receive input from midbrain dopamine neurons.
Animal models of neuropsychiatric disorders
The current state of animal models of mental illness, with a focus on schizophrenia, depression and bipolar disorder, is reviewed and it is argued for areas of focus that might increase the likelihood of creating more useful models, at least for some disorders.
A molecular and cellular theory of depression.
These findings constitute the framework for an updated molecular and cellular hypothesis of depression, which posits that stress-induced vulnerability and the therapeutic action of antidepressant treatments occur via intracellular mechanisms that decrease or increase, respectively, neurotrophic factors necessary for the survival and function of particular neurons.
New approaches to antidepressant drug discovery: beyond monoamines
This review summarizes the obstacles that have hindered the development of non-monoamine-based antidepressants, and provides a progress report on some of the most promising current strategies.