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Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus
Recent studies suggest that stress-induced atrophy and loss of hippocampal neurons may contribute to the pathophysiology of depression. The aim of this study was to investigate the effect ofExpand
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The molecular neurobiology of depression
Unravelling the pathophysiology of depression is a unique challenge. Not only are depressive syndromes heterogeneous and their aetiologies diverse, but symptoms such as guilt and suicidality areExpand
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Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions
While stressful life events are an important cause of psychopathology, most individuals exposed to adversity maintain normal psychological functioning. The molecular mechanisms underlying suchExpand
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Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress
Mice experiencing repeated aggression develop a long-lasting aversion to social contact, which can be normalized by chronic, but not acute, administration of antidepressant. Using viral-mediated,Expand
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Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
To better understand the molecular mechanisms of depression and antidepressant action, we administered chronic social defeat stress followed by chronic imipramine (a tricyclic antidepressant) to miceExpand
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Molecular basis of long-term plasticity underlying addiction
Eric J.Nestler Nature Reviews Neuroscience 2, 119– 128 (2001). In Box 1, two parts of the text read 'histone acetylase activity'. They should have read 'histone acetylation'. This correction has beenExpand
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Neural mechanisms of addiction: the role of reward-related learning and memory.
Addiction is a state of compulsive drug use; despite treatment and other attempts to control drug taking, addiction tends to persist. Clinical and laboratory observations have converged on theExpand
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Animal models of neuropsychiatric disorders
Modeling of human neuropsychiatric disorders in animals is extremely challenging given the subjective nature of many symptoms, the lack of biomarkers and objective diagnostic tests, and the earlyExpand
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A molecular and cellular theory of depression.
Recent studies have begun to characterize the actions of stress and antidepressant treatments beyond the neurotransmitter and receptor level. This work has demonstrated that long-term antidepressantExpand
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New approaches to antidepressant drug discovery: beyond monoamines
All available antidepressant medications are based on serendipitous discoveries of the clinical efficacy of two classes of antidepressants more than 50 years ago. These tricyclic and monoamineExpand
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