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DUSP6 gene

Known as: DUSP6, MKP3, PYST1 
This gene plays a role in MAP kinase dephosphorylation.
National Institutes of Health

Related topics

Related topics

7 relations
DUSP6 protein, humanDephosphorylationDual Specificity Protein Phosphatase 6Hydrolysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Serine-arginine protein kinase 1 (SRPK1) is elevated in gastric cancer and plays oncogenic functions
Serine-arginine protein kinase 1 (SRPK1) phosphorylates proteins involved in the regulation of several mRNA processing pathways… 
2013
2013
DUSP 4 expression identifies a subset of colorectal cancer tumors that differ in MAPK activation, regardless of the genotype
Abstract As dual-specificity phosphatase (DUSP) expression has been correlated to sensitivity to MEK inhibitors, DUSP expression… 
2012
2012
Dual specificity phosphatase 6 as a predictor of invasiveness in papillary thyroid cancer.
OBJECTIVE The genetic mutations causing the constitutive activation of MEK/ERK have been regarded as an initiating factor in… 
2011
2011
The genetic association of DUSP6 with bipolar disorder and its effect on ERK activity
2010
2010
DUSP5 and DUSP6 modulate corneal epithelial cell proliferation
Purpose Dual specificity phosphatases (DUSPs) modulate the duration and magnitude of phospho-activation of Erk1/2, p38 and JNK1/2… 
2010
2010
Infrequent methylation of the DUSP6 phosphatase in endometrial cancer.
Highly Cited
2009
Highly Cited
2009
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
The t(11;17)(q23;q21) translocation is associated with a retinoic acid (RA)-insensitive form of acute promyelocytic leukemia (APL… 
2008
2008
Feedback regulation of DUSP6 transcription responding to MAPK1 via ETS2 in human cells.
Highly Cited
1998
Highly Cited
1998
Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer
DUSP6 (alias PYST1), one of the dual-specificity tyrosine phosphatases, is localized on 12q21, one of the regions of frequent… 
1997
1997
Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7).
Mitogen-activated protein (MAP) kinase phosphatases constitute a growing family of dual specificity phosphatases thought to play… 
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