DUSP 4 expression identifies a subset of colorectal cancer tumors that differ in MAPK activation, regardless of the genotype.

@article{Vriendt2013DUSP4E,
  title={DUSP 4 expression identifies a subset of colorectal cancer tumors that differ in MAPK activation, regardless of the genotype.},
  author={Veerle De Vriendt and Wendy De Roock and Antonio F Di Narzo and Sun Tian and Bart Biesmans and Bart Jacobs and Eva Budinska and Xavier Sagaert and Simona Rossi and Giovanni D'Ario and Mauro Delorenzi and Iris M. Simon and Loredana Vecchione and Sabine Tejpar},
  journal={Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals},
  year={2013},
  volume={18 6},
  pages={516-24}
}
As dual-specificity phosphatase (DUSP) expression has been correlated to sensitivity to MEK inhibitors, DUSP expression levels may indicate activation of the mitogen-activated protein kinase (MAPK) pathway in many tumor types. In this study, we investigate if DUSP levels can indicate different levels of MAPK activation within colorectal cancer (CRC… CONTINUE READING