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Dual Specificity Protein Phosphatase 6

Known as: Phosphatase, MKP3, Mitogen-Activated Protein Kinase Phosphatase 3, MKP-3 Phosphatase 
A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It… 
National Institutes of Health

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DUSP1 protein, humanDUSP6 geneIn BloodProcess of secretion

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DUSP6 protein, human

Papers overview

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2014
2014
Constitutively active Ras negatively regulates Erk MAP kinase through induction of MAP kinase phosphatase 3 (MKP3) in NIH3T3 cells
The Ras/Raf/MEK/Erk signaling pathway is important for regulation of cell growth, proliferation, differentiation, survival, and… 
2012
2012
Ischemia/Reperfusion-Induced MKP-3 Impairs Endothelial NO Formation via Inactivation of ERK1/2 Pathway
Mitogen-activated protein kinase phosphatases (MKPs) are a family of dual-specificity phosphatases. Endothelial cells express… 
Highly Cited
2011
Highly Cited
2011
SIRT1 Promotes N-Myc Oncogenesis through a Positive Feedback Loop Involving the Effects of MKP3 and ERK on N-Myc Protein Stability
The N-Myc oncoprotein is a critical factor in neuroblastoma tumorigenesis which requires additional mechanisms converting a low… 
Highly Cited
2006
Highly Cited
2006
Redox regulation of MAP kinase phosphatase 3.
MAP kinase phosphatase 3 (MKP3) is a protein tyrosine phosphatase (PTP) for which in vivo evidence suggests that regulation can… 
Highly Cited
2006
Highly Cited
2006
Elevated expression of mitogen-activated protein kinase phosphatase 3 in breast tumors: a mechanism of tamoxifen resistance.
Antiestrogen resistance is a major clinical problem in the treatment of breast cancer. Altered growth factor signaling with… 
Highly Cited
2004
Highly Cited
2004
A role for MKP3 in axial patterning of the zebrafish embryo
Fibroblast growth factors (FGFs) are secreted molecules that can activate the RAS/mitogen-activated protein kinase (MAPK) pathway… 
Highly Cited
2001
Highly Cited
2001
The Mechanism of Dephosphorylation of Extracellular Signal-regulated Kinase 2 by Mitogen-activated Protein Kinase Phosphatase 3*
The mitogen-activated protein (MAP) kinase phosphatase-3 (MKP3) is a dual specificity phosphatase that specifically inactivates… 
Highly Cited
2001
Highly Cited
2001
Multiple Regions of MAP Kinase Phosphatase 3 Are Involved in Its Recognition and Activation by ERK2*
Mitogen-activated protein kinase phosphatase 3 (MKP3) is a specific regulator of extracellular signal-regulated protein kinase 2… 
Highly Cited
2000
Highly Cited
2000
Mechanistic Basis for Catalytic Activation of Mitogen-activated Protein Kinase Phosphatase 3 by Extracellular Signal-regulated Kinase*
The dual specificity mitogen-activated protein kinase phosphatase MKP3 has been shown to down-regulate mitogenic signaling… 
Highly Cited
1999
Highly Cited
1999
Mechanism of Mitogen-activated Protein Kinase Phosphatase-3 Activation by ERK2*
The mitogen-activated protein kinase phosphatase 3 (MKP3)-catalyzed hydrolysis of aryl phosphates in the absence and presence of… 
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