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DTYMK gene

Known as: THYMIDYLATE KINASE, DTYMK, TYMK 
National Institutes of Health

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thymidylate kinase

Papers overview

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Highly Cited
2005
Highly Cited
2005
Control of dTTP pool size by anaphase promoting complex/cyclosome is essential for the maintenance of genetic stability.
Anaphase promoting complex/cyclosome (APC/C)-mediated proteolysis is essential for chromosome segregation, mitotic exit, and G1… 
Highly Cited
2000
Highly Cited
2000
Potentiating AZT activation: structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP.
The 60-fold reduced phosphorylation rate of azidothymidine (AZT) monophosphate (AZTMP), the partially activated AZT metabolite… 
Highly Cited
1998
Highly Cited
1998
Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT…
The crystal structure of yeast thymidylate kinase (TmpK) complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5… 
Highly Cited
1994
Highly Cited
1994
Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth.
dTMP kinase (E.C.2.7.4.9.) catalyzes the phosphorylation of dTMP to the corresponding diphosphate. This enzyme is essential for… 
Highly Cited
1991
Highly Cited
1991
Vaccinia virus encodes an active thymidylate kinase that complements a cdc8 mutant of Saccharomyces cerevisiae.
1990
1990
CDC6 mRNA fluctuates periodically in the yeast cell cycle.
Highly Cited
1987
Highly Cited
1987
The CDC8 transcript is cell cycle regulated in yeast and is expressed coordinately with CDC9 and CDC21 at a point preceding histone transcription.
Highly Cited
1984
Highly Cited
1984
Yeast gene CDC8 encodes thymidylate kinase and is complemented by herpes thymidine kinase gene TK.
The herpes simplex virus type 1 thymidine kinase gene TK complements the defect in five temperature-sensitive mutants and in… 
Highly Cited
1984
Highly Cited
1984
The CDC8 gene of yeast encodes thymidylate kinase.
Highly Cited
1983
Highly Cited
1983
Cloning of Saccharomyces cerevisiae DNA replication genes: isolation of the CDC8 gene and two genes that compensate for the cdc8-1 mutation
The CDC8 gene, whose product is required for DNA replication in Saccharomyces cerevisiae, has been isolated on recombinant… 
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