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DNA replication preinitiation complex

Known as: DNA replication preinitiation complex location, pre-IC 
A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation… Expand
National Institutes of Health

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pre-replicative complex location

Papers overview

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2019
2019
The interaction networks of the budding yeast and human DNA replication-initiation proteins
ABSTRACT DNA replication is a stringently regulated cellular process. In proliferating cells, DNA replication-initiation proteins… Expand
2017
2017
Pre‐initiation complex assembly functions as a molecular switch that splits the Mcm2‐7 double hexamer
Initiation of chromosomal DNA replication in eukaryotes involves two steps: licensing and firing. In licensing, a core component… Expand
2017
2017
Two highly conserved features of bacterial initiator tRNAs license them to pass through distinct checkpoints in translation initiation
Abstract Eubacterial translation initiation involves assembly of tRNAfMet, mRNA, initiation factors (IFs) and 30S ribosome in a… Expand
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2012
2012
In vitro reconstitution of budding yeast pre-RC, competent in recruitment of recombinant pre-IC components, using purified, recombinant proteins
Pre-RC formation on chromosomal replication origins is an essential process for eukaryotic DNA replication in order for the… Expand
Highly Cited
2011
Highly Cited
2011
A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint
The DNA damage response in Drosophila requires the replication preinitiation complex and the MUS312 nuclease complex. Coping with… Expand
Highly Cited
2010
Highly Cited
2010
A vertebrate gene, ticrr, is an essential checkpoint and replication regulator.
Eukaryotes have numerous checkpoint pathways to protect genome fidelity during normal cell division and in response to DNA damage… Expand
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2010
2010
Initiation of DNA replication after fertilization is regulated by p90Rsk at pre-RC/pre-IC transition in starfish eggs
Initiation of DNA replication in eukaryotic cells is controlled through an ordered assembly of protein complexes at replication… Expand
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2010
2010
Analysis of metazoan DNA replication initiation using Drosophila gene amplification as a model system
Gene amplification in Drosophila follicle cells is an excellent model to study origin specification and developmental regulation… Expand
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Highly Cited
2006
Highly Cited
2006
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
Origins of DNA replication are licensed in G1 by recruiting the minichromosome maintenance (MCM) proteins to form a… Expand
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Highly Cited
1990
Highly Cited
1990
Protein-protein interactions between adenovirus DNA polymerase and nuclear factor I mediate formation of the DNA replication preinitiation complex.
The in vitro adenovirus (Ad) DNA replication system provides an assay to study the interaction of viral and host replication… Expand
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