DNA replication checkpoint

A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a… (More)
National Institutes of Health

Papers overview

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2011
2011
Human TopBP1 is a major player in the control of the DNA replication checkpoint. In this study, we identified MDC1, a key… (More)
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Highly Cited
2010
Highly Cited
2010
Human TopBP1 plays a critical role in the control of DNA replication checkpoint. In this study, we report a specific interaction… (More)
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2008
2008
Cdc7 kinase is evolutionarily conserved and is involved in initiation and progression of DNA replication. However, roles of Cdc7… (More)
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2008
2008
During replication arrest, the DNA replication checkpoint plays a crucial role in the stabilization of the replisome at stalled… (More)
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Highly Cited
2006
Highly Cited
2006
During replicative stress, Claspin mediates the phosphorylation and consequent activation of Chk1 by ATR. We found that during… (More)
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Highly Cited
2004
Highly Cited
2004
The checkpoint mediator protein Claspin is essential for the ATR-dependent activation of Chk1 in Xenopus egg extracts containing… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Acquisition of lineage-specific cell cycle duration is a central feature of metazoan development. The mechanisms by… (More)
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Highly Cited
2000
Highly Cited
2000
We have identified Claspin, a novel protein that binds to Xenopus Chk1 (Xchk1). Binding of Claspin to Xchk1 is highly elevated in… (More)
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Highly Cited
2000
Highly Cited
2000
We have examined the cellular function of Sgs1p, a nonessential yeast DNA helicase, homologs of which are implicated in two… (More)
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Review
2000
Review
2000
The eukaryotic homologues of the Escherichia coli RecQ DNA helicase play conserved roles in the maintenance of genome stability… (More)
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