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Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features.
Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial.
ATR Regulates Fragile Site Stability
Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors.
- Kelly M Garneski, Ashley H. Warcola, Q. Feng, N. Kiviat, J. Leonard, P. Nghiem
- Medicine, BiologyThe Journal of investigative dermatology
TO THE EDITOR Merkel cell carcinoma (MCC) is an increasingly common neuroendocrine cancer of the skin. MCC is an aggressive malignancy that is a significant cause of non-melanoma skin cancer…
ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation
- P. Nghiem, P. K. Park, Y. Kim, C. Vaziri, S. Schreiber
- BiologyProceedings of the National Academy of Sciences…
- 31 July 2001
It is suggested that ATR represents an attractive therapeutic target for selectively killing cancer cells by premature chromatin condensation by mimicking cancer cell phenotypes by disrupting normal G1 checkpoints by ATR inhibition plus low-dose DNA damage.
Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system.
Interactive Atlas of Dermoscopy
Analysis of Prognostic Factors from 9387 Merkel Cell Carcinoma Cases Forms the Basis for the New 8th Edition AJCC Staging System
Analysis of a national dataset of MCC cases validates the predictive value of disease extent at presentation and separation of clinical and pathological stage groups and regrouping of unknown primary tumors are supported by the analysis.
PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma.
First-line therapy with pembrolizumab in patients with advanced Merkel-cell carcinoma was associated with an objective response rate of 56% and effectiveness was correlated with tumor viral status, as assessed by serologic and immunohistochemical testing.
Association of Merkel Cell Polyomavirus–Specific Antibodies With Merkel Cell Carcinoma
- J. Carter, K. Paulson, D. Galloway
- Medicine, BiologyJournal of the National Cancer Institute
- 4 November 2009
Infection with MCPyV is common in the general population, but not other human polyomaviruses, appears to be associated with Merkel cell carcinoma.