DNA polymerase processivity factor activity

Known as: processivity clamp, sliding clamp 
An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1981-2017
010203019812017

Related topics

Related topics

2 relations

Broader (1)

DNA metabolic process

Narrower (1)

PCNA complex

Related mentions per year

Related mentions per year

1956-2018
1960198020002020
DNA polymerase processivity factor activity
DNA metabolic process
PCNA complex

Papers overview

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Highly Cited
2010
Highly Cited
2010
Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly.
Break-induced replication (BIR) is an efficient homologous recombination (HR) pathway employed to repair a DNA double-strand… (More)
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Highly Cited
2005
Highly Cited
2005
A sliding-clamp toolbelt binds high- and low-fidelity DNA polymerases simultaneously.
This report demonstrates that the beta sliding clamp of E. coli binds two different DNA polymerases at the same time. One is the… (More)
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Highly Cited
2005
Highly Cited
2005
Nuclear dynamics of PCNA in DNA replication and repair.
The DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) is central to both DNA replication and repair… (More)
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Highly Cited
2004
Highly Cited
2004
Structural analysis of a eukaryotic sliding DNA clamp–clamp loader complex
Sliding clamps are ring-shaped proteins that encircle DNA and confer high processivity on DNA polymerases. Here we report the… (More)
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2003
2003
A peptide switch regulates DNA polymerase processivity.
Chromosomal DNA polymerases are tethered to DNA by a circular sliding clamp for high processivity. However, lagging strand… (More)
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Highly Cited
2002
Highly Cited
2002
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
The RAD6 pathway is central to post-replicative DNA repair in eukaryotic cells; however, the machinery and its regulation remain… (More)
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Highly Cited
2001
Highly Cited
2001
Mechanism of Processivity Clamp Opening by the Delta Subunit Wrench of the Clamp Loader Complex of E. coli DNA Polymerase III
The dimeric ring-shaped sliding clamp of E. coli DNA polymerase III (beta subunit, homolog of eukaryotic PCNA) is loaded onto DNA… (More)
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Highly Cited
1999
Highly Cited
1999
Building a Replisome from Interacting Pieces Sliding Clamp Complexed to a Peptide from DNA Polymerase and a Polymerase Editing Complex
We have solved the crystal structures of the bacteriophage RB69 sliding clamp, its complex with a peptide essential for DNA… (More)
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Highly Cited
1999
Highly Cited
1999
UmuD'(2)C is an error-prone DNA polymerase, Escherichia coli pol V.
The damage-inducible UmuD' and UmuC proteins are required for most SOS mutagenesis in Escherichia coli. Our recent assay to… (More)
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Highly Cited
1999
Highly Cited
1999
Trading Places on DNA—A Three-Point Switch Underlies Primer Handoff from Primase to the Replicative DNA Polymerase
This study reports a primase-to-polymerase switch in E. coli that closely links primase action with extension by DNA polymerase… (More)
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