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DNA polymerase processivity factor activity

Known as: processivity clamp, sliding clamp 
An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along… Expand
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

DNA metabolic process

Narrower (1)

PCNA complex

Papers overview

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Highly Cited
2006
Highly Cited
2006
Tyrosine phosphorylation controls PCNA function through protein stability
The proliferating cell nuclear antigen (PCNA) is an essential protein for DNA replication and damage repair. How its function is… Expand
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Highly Cited
2005
Highly Cited
2005
Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p.
Posttranslational modification of proliferating cell nuclear antigen (PCNA), an essential processivity clamp for DNA polymerases… Expand
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Review
2005
Review
2005
Cellular DNA replicases: components and dynamics at the replication fork.
DNA replicases are multicomponent machines that have evolved clever strategies to perform their function. Although the structure… Expand
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Highly Cited
2004
Highly Cited
2004
Structural analysis of a eukaryotic sliding DNA clamp–clamp loader complex
Sliding clamps are ring-shaped proteins that encircle DNA and confer high processivity on DNA polymerases. Here we report the… Expand
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Highly Cited
2004
Highly Cited
2004
hMSH4-hMSH5 recognizes Holliday Junctions and forms a meiosis-specific sliding clamp that embraces homologous chromosomes.
Five MutS homologs (MSH), which form three heterodimeric protein complexes, have been identified in eukaryotes. While the human… Expand
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Review
2003
Review
2003
Proliferating cell nuclear antigen (PCNA): a dancer with many partners
Proliferating cell nuclear antigen (PCNA) was originally characterised as a DNA sliding clamp for replicative DNA polymerases and… Expand
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Highly Cited
2002
Highly Cited
2002
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
The RAD6 pathway is central to post-replicative DNA repair in eukaryotic cells; however, the machinery and its regulation remain… Expand
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Highly Cited
1999
Highly Cited
1999
Building a Replisome from Interacting Pieces Sliding Clamp Complexed to a Peptide from DNA Polymerase and a Polymerase Editing Complex
We have solved the crystal structures of the bacteriophage RB69 sliding clamp, its complex with a peptide essential for DNA… Expand
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Highly Cited
1999
Highly Cited
1999
UmuD'(2)C is an error-prone DNA polymerase, Escherichia coli pol V.
The damage-inducible UmuD' and UmuC proteins are required for most SOS mutagenesis in Escherichia coli. Our recent assay to… Expand
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Highly Cited
1991
Highly Cited
1991
Mechanism of the sliding beta-clamp of DNA polymerase III holoenzyme.
DNA polymerase III holoenzyme (holoenzyme), the multiprotein replicase of Escherichia coli, is essentially unlimited in… Expand
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