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Immunological and ultrastructural studies of the nuclear coiled body with autoimmune antibodies.
Studies with human autoimmune sera identified auto-antibodies reacting with a novel antigen of 80 kDa. In interphase mammalian cells, the 80-kDa antigen was enriched in nuclear coiled bodies and wasExpand
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Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin
Antibodies producing an unusual immunofluorescent pattern were identified in the sera of patients with diverse autoimmune features. This pattern was characterized by the presence of up to six roundExpand
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The nucleolus and transcription of ribosomal genes
Abstract Ribosome biogenesis is a highly dynamic, steady‐state nucleolar process that involves synthesis and maturation of rRNA, its transient interactions with non‐ribosomal proteins and RNPs andExpand
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New insights into nucleolar architecture and activity.
The nucleolus is the most obvious and clearly differentiated nuclear subcompartment. It is where ribosome biogenesis takes place and has been the subject of research over many decades. In recentExpand
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Association between the nucleolus and the coiled body.
By means of light and electron microscopic immunocytochemistry, we have localized p80-coilin, a specific protein marker for coiled bodies, in mammalian cell lines as well as in primary rat neuronExpand
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Nuclear pre-mRNA compartmentalization: trafficking of released transcripts to splicing factor reservoirs.
In the present study, the spatial organization of intron-containing pre-mRNAs of Epstein-Barr virus (EBV) genes relative to location of splicing factors is investigated. The intranuclear position ofExpand
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Structure and function of the nucleolus in the spotlight.
The nucleolus is the most obvious and clearly differentiated nuclear sub-compartment. It is where ribosome biogenesis takes place, but it is becoming clear that the nucleolus also has non-ribosomalExpand
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Ribosomal genes in focus
T he organization of transcriptionally active ribosomal genes in animal cell nucleoli is investigated in this study in order to address the long-standing controversy with regard to the intranucleolarExpand
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Oldies but goldies: searching for Christmas trees within the nucleolar architecture.
  • I. Raška
  • Medicine, Biology
  • Trends in cell biology
  • 1 October 2003
The nucleolus is the prominent nuclear organelle in which the biogenesis of ribosomal RNA and ribosomes takes place. Understanding of the molecular processes in the nucleolus is rapidly expanding;Expand
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The Drosophila lethal(2)giant larvae tumor suppressor protein is a component of the cytoskeleton
Tumor suppressor genes act as recessive determinants of cancer. In Drosophila these genes play a role in normal development and are essential for regulating cell growth and differentiation. MutationsExpand
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