• Publications
  • Influence
Both RadA and RadB Are Involved in Homologous Recombination inPyrococcus furiosus *
RecA and Rad51 proteins are essential for homologous recombination in Bacteria andEukarya, respectively. Homologous proteins, called RadA, have been described for Archaea. Here we present theExpand
  • 105
  • 12
Open clamp structure in the clamp-loading complex visualized by electron microscopic image analysis.
Ring-shaped sliding clamps and clamp loader ATPases are essential factors for rapid and accurate DNA replication. The clamp ring is opened and resealed at the primer-template junctions by theExpand
  • 106
  • 9
  • PDF
Architecture of the DNA polymerase B-proliferating cell nuclear antigen (PCNA)-DNA ternary complex
DNA replication in archaea and eukaryotes is executed by family B DNA polymerases, which exhibit full activity when complexed with the DNA clamp, proliferating cell nuclear antigen (PCNA). ThisExpand
  • 51
  • 7
The centromeric nucleosome-like CENP–T–W–S–X complex induces positive supercoils into DNA
The centromere is a specific genomic region upon which the kinetochore is formed to attach to spindle microtubules for faithful chromosome segregation. To distinguish this chromosomal region fromExpand
  • 65
  • 6
  • PDF
Structure and Functional Characterization of Vibrio parahaemolyticus Thermostable Direct Hemolysin*
Thermostable direct hemolysin (TDH) is a major virulence factor of Vibrio parahaemolyticus that causes pandemic foodborne enterocolitis mediated by seafood. TDH exists as a tetramer in solution, andExpand
  • 54
  • 5
Crystal structure of the Holliday junction migration motor protein RuvB from Thermus thermophilus HB8.
We report here the crystal structure of the RuvB motor protein from Thermus thermophilus HB8, which drives branch migration of the Holliday junction during homologous recombination. RuvB has aExpand
  • 77
  • 4
  • PDF
Formation and branch migration of Holliday junctions mediated by eukaryotic recombinases
Holliday junctions (HJs) are key intermediates in homologous recombination and are especially important for the production of crossover recombinants. Bacterial RecA family proteins promote theExpand
  • 45
  • 4
Two-state Conformational Changes in Inositol 1,4,5-Trisphosphate Receptor Regulated by Calcium*
Inositol 1,4,5-trisphosphate receptor (IP3R) is a highly controlled calcium (Ca2+) channel gated by inositol 1,4,5-trisphosphate (IP3). Multiple regulators modulate IP3-triggered pore opening byExpand
  • 87
  • 3
  • PDF
Two different oligomeric states of the RuvB branch migration motor protein as revealed by electron microscopy.
In prokaryotes, the RuvA, B, and C proteins play major roles at the late stage of DNA homologous recombination, where RuvB complexed with RuvA acts as an ATP-dependent motor for branch migration. TheExpand
  • 55
  • 3
Comparison of MukB homodimer versus MukBEF complex molecular architectures by electron microscopy reveals a higher-order multimerization.
The complex of MukF, MukE, and MukB proteins participates in organization of sister chromosomes and partitioning into both daughter cells in Escherichia coli. We purified the MukB homodimer and theExpand
  • 55
  • 3