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DNA Ligation

The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase. [ISBN:0815316194]
National Institutes of Health

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DNA ligase activitynuclear DNA replication DNA ligation
negative regulation of DNA ligationregulation of DNA ligation

Papers overview

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2020
2020
Towards Efficient Nonenzymatic DNA Ligation: Comparing Key Parameters for Maximizing Ligation Rates and Yields with Carbodiimide Activation **
Chemical ligation is an important tool for the generation of synthetic DNA structures, which are used for a wide range of… 
2005
2005
Tethered DNA hairpins facilitate electrochemical detection of DNA ligation.
A novel electrochemical assay for DNA ligase activity is described. The assay exploits the properties of DNA hairpins tethered at… 
2002
2002
Nucleosome linker proteins HMGB1 and histone H1 differentially enhance DNA ligation reactions.
We previously reported that HMGB1, which originally binds to chromatin in a manner competitive with linker histone H1 to modulate… 
2002
2002
Substrate recognition and fidelity of strand joining by an archaeal DNA ligase.
We have previously identified a DNA ligase (LigTk) from a hyperthermophilic archaeon, Thermococcus kodakaraensis KOD1. The enzyme… 
2002
2002
Human topoisomerase IIalpha possesses an intrinsic nucleic acid specificity for DNA ligation. Use of 5' covalently activated oligonucleotide substrates to study enzyme mechanism.
Despite the importance of topoisomerase II-mediated DNA ligation to the essential physiological functions of the enzyme, the… 
1998
1998
Apoptosis in the early human placental bed and its discrimination from necrosis using the in-situ DNA ligation technique.
Extensive areas of necrosis are present in the early human placental bed. Our aim was to determine whether apoptosis is also a… 
1995
1995
Comet assay analysis of repair of DNA strand breaks in normal and deficient human cells exposed to radiations and chemicals. Evidence for a repair pathway specificity of DNA ligation.
The induction and resealing of DNA strand breaks in a cell line with a proven defect in DNA ligase I, 46BR, and in two Bloom's… 
1994
1994
Glutathione can rescue the inhibitory effects of nickel on DNA ligation and repair synthesis.
The purpose of this investigation was to explore the reason why nickel chloride enhances the cytotoxicity and genotoxicity of… 
1994
1994
Intramolecular and intermolecular DNA ligation mediated by topoisomerase II.
The ability of topoisomerase II to mediate a number of DNA rearrangements was examined at the molecular level. For this purpose a… 
Highly Cited
1984
Highly Cited
1984
Differences in intracellular DNA ligation after microinjection and transfection.
An uninterrupted avian sarcoma viral genome terminated by viral long terminal repeat sequences was cloned into a pBR322 plasmid… 
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