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The selectivity for K+ versus Na+ in DNA quadruplexes is dominated by relative free energies of hydration: a thermodynamic analysis by 1H NMR.
We have studied the competition between Na+ and K+ for coordination by G quartets using the oligonucleotide d(G3T4G3) as a model system. d(G3T4G3) forms a dimeric foldback structure containing threeExpand
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DNA-templated Ag nanocluster formation.
The high affinity of Ag+ for DNA bases has enabled creation of short oligonucleotide-encapsulated Ag nanoclusters without formation of large nanoparticles. Time-dependent formation of cluster sizesExpand
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Formation of Native-like Mammalian Sperm Cell Chromatin with Folded Bull Protamine*
The DNA of most vertebrate sperm cells is packaged by protamines. The primary structure of mammalian protamine I can be divided into three domains, a central DNA binding domain that is arginine-richExpand
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Cryoelectron microscopy of λ phage DNA condensates in vitreous ice: The fine structure of DNA toroids
  • N. Hud, K. Downing
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 4 December 2001
DNA toroids produced by the condensation of λ phage DNA with hexammine cobalt (III) have been investigated by cryoelectron microscopy. Image resolution obtained by this technique has allowedExpand
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Controlling the size of nanoscale toroidal DNA condensates with static curvature and ionic strength
The process of DNA condensation into nanometer-scale particles has direct relevance to several fields, including cell biology, virology, and gene delivery for therapeutic purposes. DNA condensationExpand
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Evolution of the ribosome at atomic resolution
Significance Ribosomes exist in every cell and are responsible for translation from mRNA to protein. The structure of the ribosomal common core is highly conserved in all living species, while theExpand
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The effect of sodium, potassium and ammonium ions on the conformation of the dimeric quadruplex formed by the Oxytricha nova telomere repeat oligonucleotide d(G(4)T(4)G(4)).
The DNA sequence d(G(4)T(4)G(4)) [Oxy-1.5] consists of 1.5 units of the repeat in telomeres of Oxytricha nova and has been shown by NMR and X-ray crystallographic analysis to form a dimericExpand
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Cations in charge: magnesium ions in RNA folding and catalysis.
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Localization of ammonium ions in the minor groove of DNA duplexes in solution and the origin of DNA A-tract bending.
Monovalent cation binding sites on nucleic acids in solution can be localized using the isotopically labeled ammonium ion (15NH4+) as a probe in high resolution NMR spectroscopy experiments. TheExpand
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History of the ribosome and the origin of translation
Significance The ribosome, in analogy with a tree, contains a record of its history, spanning 4 billion years of life on earth. The information contained within ribosomes connects us to theExpand
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