FAQ

DNA Fragmentation

Known as: Fragmentation, DNA 
Splitting the DNA into shorter pieces by endonucleolytic DNA CLEAVAGE at multiple sites. It includes the internucleosomal DNA fragmentation, which… (More)

Topic mentions per year

Topic mentions per year

1966-2017
020040019662017

Related topics

Related topics

5 relations
DFFB geneDFFB protein, humanDFFB wt Alleleaspects of radiation effects

Narrower (1)

apoptotic DNA fragmentation

Related mentions per year

Related mentions per year

1966-2018
1960198020002020
DNA Fragmentation
apoptotic DNA fragmentation
DFFB wt Allele
DFFB gene
DFFB protein, human
aspects of radiation effects

Papers overview

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Highly Cited
2006
Highly Cited
2006
Sperm DNA fragmentation: paternal effect on early post-implantation embryo development in ART.
BACKGROUND The relationship between early embryo post-implantation development in couples undergoing assisted reproductive… (More)
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Highly Cited
2003
Highly Cited
2003
Sperm DNA fragmentation decreases the pregnancy rate in an assisted reproductive technique.
BACKGROUND Standard sperm characteristics are poor predictors of the outcome of IVF treatments. On the contrary, sperm genome… (More)
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Highly Cited
2000
Highly Cited
2000
Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139.
Histone H2AX is a ubiquitous member of the H2A histone family that differs from the other H2A histones by the presence of an… (More)
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Highly Cited
1999
Highly Cited
1999
Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation.
Caspase-3 initiates apoptotic DNA fragmentation by proteolytically inactivating DFF45 (DNA fragmentation factor-45)/ICAD… (More)
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Highly Cited
1998
Highly Cited
1998
Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis.
Interleukin 1beta-converting enzyme-like proteases (caspases) are crucial components of cell death pathways. Among the caspases… (More)
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Highly Cited
1998
Highly Cited
1998
The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis.
We report here the reconstitution of a pathway that leads to the apoptotic changes in nuclei by using recombinant DNA… (More)
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Highly Cited
1997
Highly Cited
1997
DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis
We have identified and purified from HeLa cytosol a protein that induces DNA fragmentation in coincubated nuclei after it is… (More)
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Highly Cited
1997
Highly Cited
1997
Major DNA fragmentation is a late event in apoptosis.
Apoptosis, the terminal morphological and biochemical events of programmed cell death, is characterized by specific changes in… (More)
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Highly Cited
1997
Highly Cited
1997
Detection of deoxyribonucleic acid fragmentation in human sperm: correlation with fertilization in vitro.
The objective of this study was to determine the incidence of DNA fragmentation in human sperm, and to correlate any detected DNA… (More)
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Highly Cited
1987
Highly Cited
1987
Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.
An early event in death of interphase lymphocytes exposed in vivo or in vitro to low doses of gamma-irradiation is the… (More)
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