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DNA Methylation Regulates Cocaine-Induced Behavioral Sensitization in Mice
The behavioral sensitization produced by repeated cocaine treatment represents the neural adaptations underlying some of the features of addiction in humans. Cocaine administrations induce neuralExpand
Additive effects of histone deacetylase inhibitors and amphetamine on histone H4 acetylation, cAMP responsive element binding protein phosphorylation and ΔFosB expression in the striatum and
Histone deacetylase (HDAC) plays an important role in chromatin remodeling in response to a variety of neurochemical signalings and behavioral manipulations, and may be a therapeutic target forExpand
Novel neuroprotection by caffeine and adenosine A2A receptor antagonists in animal models of Parkinson's disease
The adenosine A(2A) receptor has recently emerged as a leading non-dopaminergic therapeutic target for Parkinson's disease, largely due to the restricted distribution of the receptor in the striatumExpand
Dehydroepiandrosterone sulphate prevents oxygen–glucose deprivation-induced injury in cerebellar granule cell culture
Decreased levels of dehydroepiandrosterone sulphate have been hypothesized to contribute to increased vulnerability of the ageing or stressed human brain to ischemia. To help to address the questionExpand
Histone deacetylase inhibitors modulates the induction and expression of amphetamine-induced behavioral sensitization partially through an associated learning of the environment in mice
The behavioral sensitization produced by repeated amphetamine treatment may represent the neural adaptations underlying some of the features of psychosis and addiction in humans. ChromatinExpand
Maternal separation is associated with DNA methylation and behavioural changes in adult rats
Early life stress is known to promote long-term neurobiological changes, which may underlie the increased risk of psychopathology. Maternal separation (MS) is used as an early life stressor thatExpand
Genetic and pharmacological inactivation of the adenosine A2A receptor attenuates 3‐nitropropionic acid‐induced striatal damage
Adenosine A2A receptor (A2AR) antagonism attenuates 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced dopaminergic neurodegeneration and quinolinic acid‐induced excitotoxicity in the neostriatum.Expand
Neuroprotective action of group I metabotropic glutamate receptor agonists against oxygen–glucose deprivation-induced neuronal death
The metabotropic glutamate receptor (mGluR) non-selective agonist (1S,3R)-1-aminocycloheptane-trans-1,3-dicarboxylic acid [(1S, 3R)ACPD] and group I selective receptor agonist 3,Expand
Acute amphetamine treatment decreases the expression of 180–200 kDa isoform of polysialic acid linked neural cell adhesion molecule in mouse hippocampus
The behavioral sensitization produced by repeated treatment with amphetamine may represent neural adaptations underlying some of the features of psychosis and addiction in humans. Under someExpand
Adenosine A2A Receptors in Bone Marrow-Derived Cells But Not in Forebrain Neurons Are Important Contributors to 3-Nitropropionic Acid-Induced Striatal Damage as Revealed by Cell-Type-Selective
Endogenous adenosine acting at the adenosine A2A receptor (A2AR) can modify brain injury in a variety of neurological disorder models. However, both A2AR activation and inactivation have been shownExpand