DNA Cleavage

A reaction that severs one of the covalent sugar-phosphate linkages between NUCLEOTIDES that compose the sugar phosphate backbone of DNA. It is… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1983-2018
05101519832018

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2010
2010
Emodin, an anthraquinone derived from a plant and fungi, has been reported to possess potential genotoxicity, but the mechanism… (More)
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2008
2008
The DNA cleavage reaction of human topoisomerase IIalpha is critical to all of the physiological and pharmacological functions of… (More)
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2008
2008
DNA topoisomerase II is a molecular machine that couples ATP hydrolysis to the transport of one DNA segment through a transient… (More)
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1997
1997
We have studied the interaction of the F plasmid killer protein CcdB with its intracellular target DNA gyrase. We confirm that… (More)
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1997
1997
Rapid-reaction methods have been used previously to identify intermediates in the reaction of the EcoRV restriction endonuclease… (More)
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1992
1992
Eukaryotic topoisomerase II is capable of binding two separate nucleic acid helices prior to its DNA cleavage and strand passage… (More)
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1991
1991
The post-strand-passage DNA cleavage/religation equilibrium of Drosophila melanogaster topoisomerase II was examined. This was… (More)
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1989
1989
The DNA cleavage reaction of eukaryotic topoisomerase II produces nicked DNA along with linear nucleic acid products. Therefore… (More)
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1985
1985
In order to study the sequence specificity of double-strand DNA cleavage by Drosophila topoisomerase II, we have mapped and… (More)
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1983
1983
The purified type II DNA topoisomerase from the embryos of Drosophila melanogaster exists in its native form as a dimer of 170… (More)
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