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DNA Cleavage

A reaction that severs one of the covalent sugar-phosphate linkages between NUCLEOTIDES that compose the sugar phosphate backbone of DNA. It is… 
National Institutes of Health

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Related topics

1 relation
aspects of radiation effects

Papers overview

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Highly Cited
2014
Highly Cited
2014
Efficient hydrolytic cleavage of plasmid DNA by chloro-cobalt(II) complexes based on sterically hindered pyridyl tripod tetraamine ligands: synthesis, crystal structure and DNA cleavage.
Four new cobalt(ii) complexes [Co(6-MeTPA)Cl]ClO4/PF6 (2/2a), [Co(6-Me2TPA)Cl]ClO4/PF6 (3/3a), [Co(BPQA)Cl]ClO4/PF6 (4/4a) and… 
Highly Cited
1999
Highly Cited
1999
DNA cleavage by the EcoRV restriction endonuclease: roles of divalent metal ions in specificity and catalysis.
The roles of divalent metal ions in DNA cleavage by the EcoRV endonuclease were studied by using Co2+ or Mn2+ as substitutes for… 
Highly Cited
1997
Highly Cited
1997
Identification of a novel 97 kDa endonuclease capable of internucleosomal DNA cleavage.
The two steps of DNA digestion seen in apoptotic cells were recreated in nuclei isolated from 5123tc rat hepatoma cells. The… 
Highly Cited
1997
Highly Cited
1997
Rapid-reaction analysis of plasmid DNA cleavage by the EcoRV restriction endonuclease.
Rapid-reaction methods have been used previously to identify intermediates in the reaction of the EcoRV restriction endonuclease… 
Highly Cited
1995
Highly Cited
1995
Oxidative and nonoxidative mechanisms of site-specific DNA cleavage induced by copper-containing metallothioneins.
DNA cleavage induced by metallothionein (MT) containing copper was investigated by a DNA sequencing technique. Reconstituted Cd7… 
Highly Cited
1993
Highly Cited
1993
The mechanism of sequence-specific DNA cleavage and strand transfer by phi X174 gene A* protein.
We have examined the biological role and catalytic function of two juxtaposed tyrosyl residues in the bacteriophage phi X174 gene… 
Highly Cited
1992
Highly Cited
1992
Inhibition of HIV-1 integration protein by aurintricarboxylic acid monomers, monomer analogs, and polymer fractions.
Highly Cited
1991
Highly Cited
1991
Induction of mammalian DNA topoisomerase I and II mediated DNA cleavage by saintopin, a new antitumor agent from fungus.
Saintopin is an antitumor antibiotic recently discovered in mechanistically oriented screening using purified calf thymus DNA… 
Highly Cited
1990
Highly Cited
1990
Stabilization of the topoisomerase II-DNA cleavage complex by antineoplastic drugs: inhibition of enzyme-mediated DNA religation by 4'-(9-acridinylamino)methanesulfon-m-anisidide.
In order to elucidate the mechanism by which the intercalative antineoplastic drug 4'-(9-acridinylamino)methanesulfon-m-anisidide… 
Highly Cited
1986
Highly Cited
1986
Photosensitive DNA cleavage and phage inactivation by copper(II)-camptothecin.
Upon irradiation with 365-nm light, copper(II)-camptothecin significantly produced single- and double-strand breaks of DNA and… 
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