DL-threo-beta-benzyloxyaspartate

Known as: DL-TBOA, TBOA 
 
National Institutes of Health

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benzyloxyaspartate

Papers overview

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Highly Cited
2009
Highly Cited
2009
Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake
In Alzheimer's disease (AD), the impairment of declarative memory coincides with the accumulation of extracellular amyloid-beta… (More)
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2008
2008
Dopamine D1 receptors and group I metabotropic glutamate receptors contribute to the induction of long-term potentiation in the nucleus accumbens
Long-term changes in the efficacy of glutamatergic synaptic transmission in the striatal complex are proposed to underlie motor… (More)
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2005
2005
Differential effects of the substrate inhibitor l-trans-pyrrolidine-2,4-dicarboxylate (PDC) and the non-substrate inhibitor DL-threo-beta-benzyloxyaspartate (DL-TBOA) of glutamate transporters on…
The extracellular concentration of glutamate is highly regulated by transporter proteins, due to its neurotoxic properties… (More)
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Highly Cited
2004
Highly Cited
2004
Characterization of novel L-threo-beta-benzyloxyaspartate derivatives, potent blockers of the glutamate transporters.
Nontransportable blockers of the glutamate transporters are important tools for investigating mechanisms of synaptic transmission… (More)
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2004
2004
Facilitation of morphine withdrawal symptoms and morphine-induced conditioned place preference by a glutamate transporter inhibitor DL-threo-beta-benzyloxyaspartate in rats.
There is a body of evidence implying the involvement of the central glutamatergic system in morphine dependence. In this study… (More)
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Highly Cited
2004
Highly Cited
2004
Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons.
Clearance of extracellular glutamate is essential for limiting the activity of metabotropic glutamate receptors (mGluRs) at… (More)
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2003
2003
Neurotoxic and neuroprotective effects of the glutamate transporter inhibitor DL-threo-beta-benzyloxyaspartate (DL-TBOA) during physiological and ischemia-like conditions.
Maintenance of low extracellular glutamate ([Glu](O)) preventing excitotoxic cell death requires fast removal of glutamate from… (More)
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2003
2003
Characterization of depolarization-coupled release of glutamate from cultured mouse cerebellar granule cells using DL-threo-beta-benzyloxyaspartate (DL-TBOA) to distinguish between the vesicular and…
Release of preloaded [3H]D-aspartate in response to depolarization induced by N-methyl-D-aspartate (NMDA) or the endogenous… (More)
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2000
2000
Transporter reversal as a mechanism of glutamate release from the ischemic rat cerebral cortex: studies with DL-threo-beta-benzyloxyaspartate.
Elevated levels of the excitotoxic amino acids, glutamate and aspartate, have been implicated in the pathogenesis of neuronal… (More)
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Highly Cited
1998
Highly Cited
1998
DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters.
DL-threo-beta-Benzyloxyaspartate (DL-TBOA), a novel derivative of DL-threo-beta-hydroxyaspartate, was synthesized and examined as… (More)
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