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DHFR gene

Known as: DHFR, DIHYDROFOLATE REDUCTASE, Dihydrofolate Reductase Gene 
This gene is involved in biosynthesis, nucleotide metabolism and the immune response.
National Institutes of Health

Related topics

Related topics

7 relations
AnabolismAnemia, MegaloblasticDHFR PSEUDOGENESDihydrofolate Reductase, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Characterization of a novel trimethoprim resistance gene, dfrA28, in class 1 integron of an oligotrophic Acinetobacter johnsonii strain, MB52, isolated from River Mahananda, India.
The present work has validated the capability of using diluted Luria broth (10(-3)) and its amendment with antibiotics to… 
Highly Cited
2007
Highly Cited
2007
Pravastatin Enhances Beneficial Effects of Olmesartan on Vascular Injury of Salt-Sensitive Hypertensive Rats, via Pleiotropic Effects
Objective—This work was undertaken to investigate comparative effect of AT1 receptor blocker (ARB), 3-hydroxy-3-methylglutaryl… 
2006
2006
Coupling of protein motions and hydrogen transfer during catalysis by Escherichia coli dihydrofolate reductase.
The enzyme DHFR (dihydrofolate reductase) catalyses hydride transfer from NADPH to, and protonation of, dihydrofolate. The… 
2006
2006
Structure-Activity Relationships of Bacillus cereus and Bacillus anthracis Dihydrofolate Reductase: toward the Identification of New Potent Drug Leads
ABSTRACT New and improved therapeutics are needed for Bacillus anthracis, the etiological agent of anthrax. To date… 
1991
1991
Effect of specific enzyme inhibitors on replication, total genome DNA repair and on gene-specific DNA repair after UV irradiation in CHO cells.
Highly Cited
1989
Highly Cited
1989
Dual bidirectional promoters at the mouse dhfr locus: cloning and characterization of two mRNA classes of the divergently transcribed Rep-1 gene
The mouse dihydrofolate reductase gene (dhfr) is a housekeeping gene expressed under the control of a promoter region embedded in… 
1987
1987
prtR enhances the mRNA level of the Bacillus subtilis extracellular proteases
Studies were performed on the prtR gene which enhances the production of the Bacillus subtilis extracellular proteases and… 
Highly Cited
1986
Highly Cited
1986
Retroviral transfer of genes into canine hemopoietic progenitor cells in culture: a model for human gene therapy.
Amphotropic retroviral vectors containing either a mutant dihydrofolate reductase gene (DHFR) or the bacterial neomycin… 
Highly Cited
1983
Highly Cited
1983
Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea
We investigated various parameters associated with the initial selection of mouse 3T6 cells for resistance to single… 
Highly Cited
1983
Highly Cited
1983
The nucleotide sequence of the trimethoprim-resistant dihydrofolate reductase gene harbored by Tn7.
The complete nucleotide sequence of the type I dihydrofolate reductase gene from Tn7 was determined. The structural gene coded… 
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