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DC 159a
Known as:
DC-159a
, DC159a
National Institutes of Health
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Papers overview
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2016
2016
DC-159a Shows Inhibitory Activity against DNA Gyrases of Mycobacterium leprae
Tomoyuki Yamaguchi
,
Kazumasa Yokoyama
,
C. Nakajima
,
Yasuhiko Suzuki
PLoS neglected tropical diseases
2016
Corpus ID: 11560002
Background Fluoroquinolones are a class of antibacterial agents used for leprosy treatment. Some new fluoroquinolones have been…
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Review
2012
Review
2012
Tuberculosis: the drug development pipeline at a glance.
Baptiste Villemagne
,
Céline Crauste
,
Marion Flipo
,
A. Baulard
,
B. Déprez
,
N. Willand
European journal of medicinal chemistry
2012
Corpus ID: 24662134
2011
2011
Activity of the Fluoroquinolone DC-159a in the Initial and Continuation Phases of Treatment of Murine Tuberculosis
Z. Ahmad
,
Austin Minkowski
,
+4 authors
E. Nuermberger
Antimicrobial Agents and Chemotherapy
2011
Corpus ID: 33587165
ABSTRACT DC-159a is a new fluoroquinolone with more potent in vitro activity than available fluoroquinolones against both drug…
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2011
2011
Characteristic Resistance Mechanism of Mycobacterium tuberculosis to DC-159a, a New Respiratory Quinolone
Jun‐ichiro Sekiguchi
,
A. Disratthakit
,
S. Maeda
,
N. Doi
Antimicrobial Agents and Chemotherapy
2011
Corpus ID: 206699766
ABSTRACT A G88C mutation in GyrA is one of the key alterations by which Mycobacterium tuberculosis mutants acquire DC-159a…
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2010
2010
In Vitro Activities of DC-159a, a Novel Fluoroquinolone, against Mycobacterium Species
A. Disratthakit
,
N. Doi
Antimicrobial Agents and Chemotherapy
2010
Corpus ID: 10069542
ABSTRACT The in vitro activities of DC-159a against seven species of Mycobacterium were compared with moxifloxacin, gatifloxacin…
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2008
2008
Dual-targeting properties of the 3-aminopyrrolidyl quinolones, DC-159a and sitafloxacin, against DNA gyrase and topoisomerase IV: contribution to reducing in vitro emergence of quinolone-resistant…
R. Okumura
,
T. Hirata
,
Y. Onodera
,
K. Hoshino
,
T. Otani
,
Tomoko Yamamoto
The Journal of antimicrobial chemotherapy
2008
Corpus ID: 31236509
OBJECTIVES DC-159a (a novel quinolone) and sitafloxacin (DU-6859a) are structurally related quinolones, bearing a 3…
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2008
2008
Antimicrobial Activity of DC-159a, a New Fluoroquinolone, against 1,149 Recently Collected Clinical Isolates
Ronald N. Jones
,
T. Fritsche
,
H. Sader
Antimicrobial Agents and Chemotherapy
2008
Corpus ID: 25126709
ABSTRACT The activity of DC-159a, a novel orally administered fluorinated quinolone, was evaluated by reference broth…
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2008
2008
Comparative In Vitro Activities of the Investigational Fluoroquinolone DC-159a and Other Antimicrobial Agents against Human Mycoplasmas and Ureaplasmas
K. Waites
,
D. Crabb
,
L. Duffy
Antimicrobial Agents and Chemotherapy
2008
Corpus ID: 44997801
ABSTRACT The in vitro susceptibilities of 151 unique clinical isolates of Mycoplasma pneumoniae, Mycoplasma hominis, Mycoplasma…
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Highly Cited
2007
Highly Cited
2007
In Vitro and In Vivo Antibacterial Activities of DC-159a, a New Fluoroquinolone
K. Hoshino
,
Kazue Inoue
,
+7 authors
T. Otani
Antimicrobial Agents and Chemotherapy
2007
Corpus ID: 1423132
ABSTRACT DC-159a is a new 8-methoxy fluoroquinolone that possesses a broad spectrum of antibacterial activity, with extended…
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2007
2007
In Vitro Activity of DC-159a, a New Broad-Spectrum Fluoroquinolone, Compared with That of Other Agents against Drug-Susceptible and -Resistant Pneumococci
C. Clark
,
Kathy Smith
,
+4 authors
P. Appelbaum
Antimicrobial Agents and Chemotherapy
2007
Corpus ID: 24760146
ABSTRACT DC-159a yielded MICs of ≤1 μg/ml against 316 strains of both quinolone-susceptible and -resistant pneumococci…
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