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DC 159a

Known as: DC-159a, DC159a 
 
National Institutes of Health

Papers overview

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2016
2016
DC-159a Shows Inhibitory Activity against DNA Gyrases of Mycobacterium leprae
BACKGROUND Fluoroquinolones are a class of antibacterial agents used for leprosy treatment. Some new fluoroquinolones have been… Expand
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2011
2011
Activity of the fluoroquinolone DC-159a in the initial and continuation phases of treatment of murine tuberculosis.
DC-159a is a new fluoroquinolone with more potent in vitro activity than available fluoroquinolones against both drug-susceptible… Expand
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2011
2011
Characteristic resistance mechanism of Mycobacterium tuberculosis to DC-159a, a new respiratory quinolone.
A G88C mutation in GyrA is one of the key alterations by which Mycobacterium tuberculosis mutants acquire DC-159a resistance in… Expand
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2010
2010
In vitro activities of DC-159a, a novel fluoroquinolone, against Mycobacterium species.
The in vitro activities of DC-159a against seven species of Mycobacterium were compared with moxifloxacin, gatifloxacin… Expand
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2010
2010
Chondrotoxicity and toxicokinetics of novel quinolone antibacterial agents DC-159a and DX-619 in juvenile rats.
Quinolone antibacterial agents are extensively utilized in antimicrobial chemotherapy. However, they have been reported to induce… Expand
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2008
2008
Dual-targeting properties of the 3-aminopyrrolidyl quinolones, DC-159a and sitafloxacin, against DNA gyrase and topoisomerase IV: contribution to reducing in vitro emergence of quinolone-resistant…
OBJECTIVES DC-159a (a novel quinolone) and sitafloxacin (DU-6859a) are structurally related quinolones, bearing a 3… Expand
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2008
2008
In vitro and in vivo antibacterial activities of DC-159a, a new fluoroquinolone.
DC-159a is a new 8-methoxy fluoroquinolone that possesses a broad spectrum of antibacterial activity, with extended activity… Expand
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2008
2008
Antimicrobial activity of DC-159a, a new fluoroquinolone, against 1,149 recently collected clinical isolates.
The activity of DC-159a, a novel orally administered fluorinated quinolone, was evaluated by reference broth microdilution or… Expand
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2008
2008
Comparative in vitro activities of the investigational fluoroquinolone DC-159a and other antimicrobial agents against human mycoplasmas and ureaplasmas.
The in vitro susceptibilities of 151 unique clinical isolates of Mycoplasma pneumoniae, Mycoplasma hominis, Mycoplasma fermentans… Expand
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2008
2008
In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci.
DC-159a yielded MICs of <or=1 mug/ml against 316 strains of both quinolone-susceptible and -resistant pneumococci (resistance was… Expand
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