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DC 159a

Known as: DC-159a, DC159a 
 
National Institutes of Health

Papers overview

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2016
2016
DC-159a Shows Inhibitory Activity against DNA Gyrases of Mycobacterium leprae
Background Fluoroquinolones are a class of antibacterial agents used for leprosy treatment. Some new fluoroquinolones have been… Expand
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2011
2011
Characteristic Resistance Mechanism of Mycobacterium tuberculosis to DC-159a, a New Respiratory Quinolone
ABSTRACT A G88C mutation in GyrA is one of the key alterations by which Mycobacterium tuberculosis mutants acquire DC-159a… Expand
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2011
2011
Activity of the Fluoroquinolone DC-159a in the Initial and Continuation Phases of Treatment of Murine Tuberculosis
ABSTRACT DC-159a is a new fluoroquinolone with more potent in vitro activity than available fluoroquinolones against both drug… Expand
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2010
2010
In Vitro Activities of DC-159a, a Novel Fluoroquinolone, against Mycobacterium Species
ABSTRACT The in vitro activities of DC-159a against seven species of Mycobacterium were compared with moxifloxacin, gatifloxacin… Expand
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2010
2010
Chondrotoxicity and toxicokinetics of novel quinolone antibacterial agents DC-159a and DX-619 in juvenile rats.
Quinolone antibacterial agents are extensively utilized in antimicrobial chemotherapy. However, they have been reported to induce… Expand
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2008
2008
Dual-targeting properties of the 3-aminopyrrolidyl quinolones, DC-159a and sitafloxacin, against DNA gyrase and topoisomerase IV: contribution to reducing in vitro emergence of quinolone-resistant…
OBJECTIVES DC-159a (a novel quinolone) and sitafloxacin (DU-6859a) are structurally related quinolones, bearing a 3… Expand
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2008
2008
Antimicrobial Activity of DC-159a, a New Fluoroquinolone, against 1,149 Recently Collected Clinical Isolates
ABSTRACT The activity of DC-159a, a novel orally administered fluorinated quinolone, was evaluated by reference broth… Expand
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2008
2008
Comparative In Vitro Activities of the Investigational Fluoroquinolone DC-159a and Other Antimicrobial Agents against Human Mycoplasmas and Ureaplasmas
ABSTRACT The in vitro susceptibilities of 151 unique clinical isolates of Mycoplasma pneumoniae, Mycoplasma hominis, Mycoplasma… Expand
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Highly Cited
2007
Highly Cited
2007
In Vitro and In Vivo Antibacterial Activities of DC-159a, a New Fluoroquinolone
ABSTRACT DC-159a is a new 8-methoxy fluoroquinolone that possesses a broad spectrum of antibacterial activity, with extended… Expand
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2007
2007
In Vitro Activity of DC-159a, a New Broad-Spectrum Fluoroquinolone, Compared with That of Other Agents against Drug-Susceptible and -Resistant Pneumococci
ABSTRACT DC-159a yielded MICs of ≤1 μg/ml against 316 strains of both quinolone-susceptible and -resistant pneumococci… Expand
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