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D 617

Known as: D-617 
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Influence of rifampicin on the expression and function of human intestinal cytochrome P450 enzymes.
AIMS To investigate the potential induction by rifampicin of intestinal CYP2C8, CYP2C9, CYP2D6 and CYP3A4 using preparations of… 
Highly Cited
2004
Highly Cited
2004
Cytochrome P450 3A4 and P‐glycoprotein Expression in Human Small Intestinal Enterocytes and Hepatocytes: A Comparative Analysis in Paired Tissue Specimens
Highly Cited
2004
Highly Cited
2004
Identification of P450 enzymes involved in metabolism of verapamil in humans
SummaryThe calcium channel blocker verapamil[2,8-bis-(3,4-dimethoxyphenyl)-6-methyl-2-isopropyl-6-azaoctanitrile] is widely used… 
Highly Cited
2004
Highly Cited
2004
Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans
The calcium channel blocker verapamil [2,8-bis-(3,4-dimethoxyphenyl)-6-methyl-2-isopropyl-6-azaoctanitrile] undergoes extensive… 
Highly Cited
2002
Highly Cited
2002
Piperine, a Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4
Dietary constituents (e.g., in grapefruit juice; NaCl) and phytochemicals (e.g., St. John's wort) are important agents modifying… 
Highly Cited
2001
Highly Cited
2001
The impact of P‐glycoprotein efflux on enterocyte residence time and enterocyte‐based metabolism of verapamil
P‐glycoprotein (P‐gp) can limit the intestinal permeability of a number of compounds and may therefore influence their exposure… 
Highly Cited
2000
Highly Cited
2000
Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein.
Verapamil is subject to extensive oxidative metabolism mediated by cytochrome P450 enzymes with less than 5% of an oral dose… 
2000
2000
Rapid and highly sensitive method for the determination of verapamil, [2H7]verapamil and metabolites in biological fluids by liquid chromatography-mass spectrometry.
Highly Cited
1999
Highly Cited
1999
Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil.
AIMS The present study was conducted to evaluate metabolism of the enantiomers of verapamil and norverapamil using a broad range… 
Highly Cited
1990
Highly Cited
1990
Interaction of verapamil and cimetidine: stereochemical aspects of drug metabolism, drug disposition and drug action.
The pharmacokinetics, metabolism and pharmacodynamics of verapamil (160 mg p.o. of a pseudoracemic mixture) were evaluated in six… 
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