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D 617

Known as: D-617 
 
National Institutes of Health

Papers overview

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2005
2005
AIMS To investigate the potential induction by rifampicin of intestinal CYP2C8, CYP2C9, CYP2D6 and CYP3A4 using preparations of… Expand
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Highly Cited
2004
Highly Cited
2004
OBJECTIVES Our objectives were to determine the content of cytochrome P450 (CYP) 3A4, CYP3A5, and P-glycoprotein and to measure… Expand
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Highly Cited
2002
Highly Cited
2002
Dietary constituents (e.g., in grapefruit juice; NaCl) and phytochemicals (e.g., St. John's wort) are important agents modifying… Expand
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2001
2001
P-glycoprotein (P-gp) can limit the intestinal permeability of a number of compounds and may therefore influence their exposure… Expand
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Highly Cited
2000
Highly Cited
2000
Verapamil is subject to extensive oxidative metabolism mediated by cytochrome P450 enzymes with less than 5% of an oral dose… Expand
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Highly Cited
1999
Highly Cited
1999
AIMS The present study was conducted to evaluate metabolism of the enantiomers of verapamil and norverapamil using a broad range… Expand
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1998
1998
AbstractObjective: To investigate the effect of grapefruit juice (GJ) on the pharmacokinetics of orally administered verapamil in… Expand
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1995
1995
The calcium channel blocker verapamil [2,8-bis-(3,4-dimethoxyphenyl)-6-methyl-2-isopropyl-6-azaoctanitrile] undergoes extensive… Expand
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Highly Cited
1993
Highly Cited
1993
SummaryThe calcium channel blocker verapamil[2,8-bis-(3,4-dimethoxyphenyl)-6-methyl-2-isopropyl-6-azaoctanitrile] is widely used… Expand
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1990
1990
The pharmacokinetics, metabolism and pharmacodynamics of verapamil (160 mg p.o. of a pseudoracemic mixture) were evaluated in six… Expand
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