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D 617

Known as: D-617 
 
National Institutes of Health

Papers overview

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2005
2005
Influence of rifampicin on the expression and function of human intestinal cytochrome P450 enzymes.
AIMS To investigate the potential induction by rifampicin of intestinal CYP2C8, CYP2C9, CYP2D6 and CYP3A4 using preparations of… Expand
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Highly Cited
2004
Highly Cited
2004
Cytochrome P450 3A4 and P-glycoprotein expression in human small intestinal enterocytes and hepatocytes: a comparative analysis in paired tissue specimens.
OBJECTIVES Our objectives were to determine the content of cytochrome P450 (CYP) 3A4, CYP3A5, and P-glycoprotein and to measure… Expand
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Highly Cited
2002
Highly Cited
2002
Piperine, a Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4
Dietary constituents (e.g., in grapefruit juice; NaCl) and phytochemicals (e.g., St. John's wort) are important agents modifying… Expand
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2001
2001
The impact of P-glycoprotein efflux on enterocyte residence time and enterocyte-based metabolism of verapamil.
P-glycoprotein (P-gp) can limit the intestinal permeability of a number of compounds and may therefore influence their exposure… Expand
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Highly Cited
2000
Highly Cited
2000
Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein.
Verapamil is subject to extensive oxidative metabolism mediated by cytochrome P450 enzymes with less than 5% of an oral dose… Expand
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Highly Cited
1999
Highly Cited
1999
Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil.
AIMS The present study was conducted to evaluate metabolism of the enantiomers of verapamil and norverapamil using a broad range… Expand
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1998
1998
The effect of grapefruit juice on the pharmacokinetics of orally administered verapamil
AbstractObjective: To investigate the effect of grapefruit juice (GJ) on the pharmacokinetics of orally administered verapamil in… Expand
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1995
1995
Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans
The calcium channel blocker verapamil [2,8-bis-(3,4-dimethoxyphenyl)-6-methyl-2-isopropyl-6-azaoctanitrile] undergoes extensive… Expand
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Highly Cited
1993
Highly Cited
1993
Identification of P450 enzymes involved in metabolism of verapamil in humans
SummaryThe calcium channel blocker verapamil[2,8-bis-(3,4-dimethoxyphenyl)-6-methyl-2-isopropyl-6-azaoctanitrile] is widely used… Expand
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1990
1990
Interaction of verapamil and cimetidine: stereochemical aspects of drug metabolism, drug disposition and drug action.
The pharmacokinetics, metabolism and pharmacodynamics of verapamil (160 mg p.o. of a pseudoracemic mixture) were evaluated in six… Expand
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