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D 617
Known as:
D-617
Â
Â
Topic mentions per year
Topic mentions per year
1986-2002
0
1
2
3
1986
2002
Papers overview
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2003
2003
Verapamil: metabolism in cultures of primary human coronary arterial endothelial cells.
Jürgen Borlak
,
Markus Walles
,
Karsten Levsen
,
Thomas Thum
Drug metabolism and disposition: the biological…
2003
Endothelium is a metabolically active secretory tissue and an important barrier for metabolic products. Little is known about its…Â
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Highly Cited
2002
Highly Cited
2002
Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4.
Rajinder K Bhardwaj
,
Hartmut Glaeser
,
Laurent Becquemont
,
Ulrich Klotz
,
Suresh Kumar Gupta
,
Martin F. Fromm
The Journal of pharmacology and experimental…
2002
Dietary constituents (e.g., in grapefruit juice; NaCl) and phytochemicals (e.g., St. John's wort) are important agents modifying…Â
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2001
2001
The impact of P-glycoprotein efflux on enterocyte residence time and enterocyte-based metabolism of verapamil.
B. M. Johnson
,
William Neil Charman
,
C. Porter
The Journal of pharmacy and pharmacology
2001
P-glycoprotein (P-gp) can limit the intestinal permeability of a number of compounds and may therefore influence their exposure…Â
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2000
2000
Rapid and highly sensitive method for the determination of verapamil, [2H7]verapamil and metabolites in biological fluids by liquid chromatography-mass spectrometry.
Oliver von Richter
,
Michel F Eichelbaum
,
Frank Schönberger
,
U. Hofmann
Journal of chromatography. B, Biomedical sciences…
2000
A rapid and highly sensitive method for the determination of verapamil [2,8-bis-(3,4-dimethoxyphenyl)-6-methyl-2-isopropyl-6…Â
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2000
2000
Verapamil metabolite exposure in older and younger men during steady-state oral verapamil administration.
Darrell R. Abernethy
,
Irving W Wainer
,
Alexandre Anacleto
Drug metabolism and disposition: the biological…
2000
To determine the effect of age on exposure to the circulating major verapamil metabolites norverapamil, N-dealkylverapamil (D-617…Â
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1999
1999
Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil.
Timothy S. Tracy
,
Kenneth Ray Korzekwa
,
F. J. González
,
Irving W Wainer
British journal of clinical pharmacology
1999
AIMS The present study was conducted to evaluate metabolism of the enantiomers of verapamil and norverapamil using a broad range…Â
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1998
1998
The effect of grapefruit juice on the pharmacokinetics of orally administered verapamil
Ronit Zaidenstein
,
Victor Dishi
,
+5 authors
Alejandra M Golik
European Journal of Clinical Pharmacology
1998
Objective: To investigate the effect of grapefruit juice (GJ) on the pharmacokinetics of orally administered verapamil in…Â
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1995
1995
Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans
Dagmar Busse
,
José Arturo Granados Cosme
,
+5 authors
Michel F Eichelbaum
Naunyn-Schmiedeberg's Archives of Pharmacology
1995
The calcium channel blocker verapamil [2,8-bis-(3,4-dimethoxyphenyl)-6-methyl-2-isopropyl-6-azaoctanitrile] undergoes extensive…Â
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Highly Cited
1993
Highly Cited
1993
Identification of P450 enzymes involved in metabolism of verapamil in humans
Heyo Klaus Kroemer
,
J. C. Gautier
,
Philipe Beaune
,
Colin Henderson
,
C. Roland Wolf
,
Michel F Eichelbaum
Naunyn-Schmiedeberg's Archives of Pharmacology
1993
The calcium channel blocker verapamil[2,8-bis-(3,4-dimethoxyphenyl)-6-methyl-2-isopropyl-6-azaoctanitrile] is widely used in the…Â
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1990
1990
Interaction of verapamil and cimetidine: stereochemical aspects of drug metabolism, drug disposition and drug action.
Gerd Mikus
,
Michel F Eichelbaum
,
C. Fischer
,
Stanislaw W. Gumulka
,
Uwe Klotz
,
Herrmann Krömer
The Journal of pharmacology and experimental…
1990
The pharmacokinetics, metabolism and pharmacodynamics of verapamil (160 mg p.o. of a pseudoracemic mixture) were evaluated in six…Â
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