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D 617

Known as: D-617 
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
AIMS To investigate the potential induction by rifampicin of intestinal CYP2C8, CYP2C9, CYP2D6 and CYP3A4 using preparations of… Expand
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Highly Cited
2004
Highly Cited
2004
Our objectives were to determine the content of cytochrome P450 (CYP) 3A4, CYP3A5, and P‐glycoprotein and to measure CYP3A4… Expand
Highly Cited
2004
Highly Cited
2004
The calcium channel blocker verapamil [2,8-bis-(3,4-dimethoxyphenyl)-6-methyl-2-isopropyl-6-azaoctanitrile] undergoes extensive… Expand
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Highly Cited
2004
Highly Cited
2004
SummaryThe calcium channel blocker verapamil[2,8-bis-(3,4-dimethoxyphenyl)-6-methyl-2-isopropyl-6-azaoctanitrile] is widely used… Expand
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Highly Cited
2002
Highly Cited
2002
Dietary constituents (e.g., in grapefruit juice; NaCl) and phytochemicals (e.g., St. John's wort) are important agents modifying… Expand
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Highly Cited
2000
Highly Cited
2000
Verapamil is subject to extensive oxidative metabolism mediated by cytochrome P450 enzymes with less than 5% of an oral dose… Expand
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2000
2000
A rapid and highly sensitive method for the determination of verapamil [2,8-bis-(3,4-dimethoxyphenyl)-6-methyl-2-isopropyl-6… Expand
Highly Cited
1999
Highly Cited
1999
AIMS The present study was conducted to evaluate metabolism of the enantiomers of verapamil and norverapamil using a broad range… Expand
1998
1998
AbstractObjective: To investigate the effect of grapefruit juice (GJ) on the pharmacokinetics of orally administered verapamil in… Expand
Highly Cited
1990
Highly Cited
1990
The pharmacokinetics, metabolism and pharmacodynamics of verapamil (160 mg p.o. of a pseudoracemic mixture) were evaluated in six… Expand