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D 617

Known as: D-617 
 

Topic mentions per year

Topic mentions per year

1986-2002
012319862002

Papers overview

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2003
2003
Verapamil: metabolism in cultures of primary human coronary arterial endothelial cells.
Endothelium is a metabolically active secretory tissue and an important barrier for metabolic products. Little is known about its… (More)
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Highly Cited
2002
Highly Cited
2002
Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4.
Dietary constituents (e.g., in grapefruit juice; NaCl) and phytochemicals (e.g., St. John's wort) are important agents modifying… (More)
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2001
2001
The impact of P-glycoprotein efflux on enterocyte residence time and enterocyte-based metabolism of verapamil.
P-glycoprotein (P-gp) can limit the intestinal permeability of a number of compounds and may therefore influence their exposure… (More)
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2000
2000
Rapid and highly sensitive method for the determination of verapamil, [2H7]verapamil and metabolites in biological fluids by liquid chromatography-mass spectrometry.
A rapid and highly sensitive method for the determination of verapamil [2,8-bis-(3,4-dimethoxyphenyl)-6-methyl-2-isopropyl-6… (More)
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2000
2000
Verapamil metabolite exposure in older and younger men during steady-state oral verapamil administration.
To determine the effect of age on exposure to the circulating major verapamil metabolites norverapamil, N-dealkylverapamil (D-617… (More)
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1999
1999
Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil.
AIMS The present study was conducted to evaluate metabolism of the enantiomers of verapamil and norverapamil using a broad range… (More)
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1998
1998
The effect of grapefruit juice on the pharmacokinetics of orally administered verapamil
Objective: To investigate the effect of grapefruit juice (GJ) on the pharmacokinetics of orally administered verapamil in… (More)
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1995
1995
Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans
The calcium channel blocker verapamil [2,8-bis-(3,4-dimethoxyphenyl)-6-methyl-2-isopropyl-6-azaoctanitrile] undergoes extensive… (More)
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Highly Cited
1993
Highly Cited
1993
Identification of P450 enzymes involved in metabolism of verapamil in humans
The calcium channel blocker verapamil[2,8-bis-(3,4-dimethoxyphenyl)-6-methyl-2-isopropyl-6-azaoctanitrile] is widely used in the… (More)
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1990
1990
Interaction of verapamil and cimetidine: stereochemical aspects of drug metabolism, drug disposition and drug action.
The pharmacokinetics, metabolism and pharmacodynamics of verapamil (160 mg p.o. of a pseudoracemic mixture) were evaluated in six… (More)
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