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The use of Weibull distribution to describe thein vivo absorption kinetics
  • V. K. Piotrovskii
  • Chemistry, Medicine
  • Journal of Pharmacokinetics and Biopharmaceutics
  • 1 December 1987
The drug in vivoabsorption rate reflects the distribution of drug molecules absorption times. For the latter the Weibull distribution is suggested and some examples taken from the literature are usedExpand
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Identification of a prazosin metabolite and some preliminary data on its kinetics in hypertensive patients
SummaryA metabolite of prazosin was detected in serum from hypertensive patients treated with prazosin. Its structure as 2-(1-piperazinyl)-4-amino-6,7-dimethoxyquinazoline was established by UV, IR,Expand
  • 7
  • 1
[The absence of stereoselectivity in propranolol uptake by the lungs].
Propranolol (P) is known to be actively captured by the lungs of experimental animal and man. To elucidate the mechanism of the phenomenon, the authors studied the P enantiomeric ratio in the serumExpand
  • 1
  • 1
The effect of oral verapamil therapy on antipyrine clearance.
The influence of chronic verapamil treatment on antipyrine elimination was studied in eight angina patients. Antipyrine half-life (mean +/- s.d.) was 13.1 +/- 1.15 h at the start of therapy and 16.6Expand
  • 22
Development of tolerance to nifedipine in patients with stable angina pectoris.
1. The possibility of development of tolerance to the anti-ischaemic and anti-anginal effects of nifedipine during sustained administration for 2 months was studied in 15 patients with stable anginaExpand
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Disposition kinetics and urinary excretion of verapamil and some of its primary metabolites after oral administration in patients with angina pectoris.
Pharmacokinetics of verapamil and of its three primary metabolites [norverapamil, 2-(3,4-dimethoxyphenyl)-2-isopropyl-6-azaheptanitrile (D-617) andExpand
  • 7