Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans

@article{Busse1995CytochromesOT,
  title={Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans},
  author={Dagmar Busse and Jose Cosme and Philippe H. Beaune and Heyo Klaus Kroemer and Michel F Eichelbaum},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1995},
  volume={353},
  pages={116-121}
}
The calcium channel blocker verapamil [2,8-bis-(3,4-dimethoxyphenyl)-6-methyl-2-isopropyl-6-azaoctanitrile] undergoes extensive biotransformation in man. We have previously demonstrated cytochrome P450 (CYP) 3A4 and 1A2 to be the enzymes responsible for verapamil N-dealkylation (formation of D-617 [2-(3,4-dimethoxyphenyl)-5-methylamino-2-isopropylvaleronitrile]), and verapamil N-demethylation (formation of norverapamil [2,8-bis(3,4-dimethoxyphenyl)-2-isopropyl-6-azaoctanitrile]), while there… CONTINUE READING

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References

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Biochemistry and molecular biology of the human CYP 2 C subfamily

  • JA Goldstein, de Morais SMF
  • Pharmacogenetics
  • 1994

Identifi - cation of cytochrome P 450 enzymes involved in the metabolism of antipyrin : potential and limitations of different in vitro techniques

  • G Engel, U Hofmann, H Heidemann, M Eichelbanm
  • Naunyn - Schmiedeberg ' s Arch Pharmacol
  • 1994

Identification of cytochrome P450 enzymes involved in the metabolism of antipyrin: potential and limitations of different in vitro

  • G Engel, U Hofmann, H Heidemann, M Eichelbanm
  • 1994
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