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Cytoplasmic Aspartate Aminotransferase

Known as: Aspartate Aminotransferase, Cytoplasmic [Chemical/Ingredient], GOT1, Glutamate Oxaloacetate-Transaminase-1 
Aspartate aminotransferase, cytoplasmic (413 aa, ~46 kDa) is encoded by the human GOT1 gene. This protein is involved in amino acid metabolism.
National Institutes of Health

Related topics

Related topics

15 relations

Broader (1)

Aspartate Transaminase
Enzyme GeneGOT1 geneIn BloodMalate-Aspartate Shuttle Pathway

Papers overview

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Highly Cited
2019
Highly Cited
2019
miR-9-5p inhibits pancreatic cancer cell proliferation, invasion and glutamine metabolism by targeting GOT1.
2019
2019
Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism
Distinctive from their normal counterparts, cancer cells exhibit unique metabolic dependencies on glutamine to fuel anabolic… 
Highly Cited
2018
Highly Cited
2018
miR‐9 regulates ferroptosis by targeting glutamic‐oxaloacetic transaminase GOT1 in melanoma
Ferroptosis is a recently recognized form of regulated cell death driven by lipid‐based reactive oxygen species (ROS… 
Highly Cited
2017
Highly Cited
2017
GOT1-mediated anaplerotic glutamine metabolism regulates chronic acidosis stress in pancreatic cancer cells.
Highly Cited
2010
Highly Cited
2010
Effects of sulfur dioxide on hypoxic pulmonary vascular structural remodeling
Hypoxic pulmonary hypertension is a pathophysiological process important in the development of various cardiopulmonary diseases… 
2009
2009
High level of genetic differentiation of Juniperus phoenicea (Cupressaceae) in the Mediterranean region: geographic implications
Fourteen natural populations of Juniperus phoenicea L. from the quite entire species range have been compared using isoenzyme… 
Highly Cited
2005
Highly Cited
2005
Differentially expressed transcripts from phenotypically identified olfactory sensory neurons
In comparing purified mouse olfactory sensory neurons (OSNs) with neighboring cells, we identified 54 differentially expressed… 
2003
2003
Biodistribution of 111in-DTPA-D-Phe1-octreotide in tumor-bearing nude mice: influence of amount injected and route of administration.
1986
1986
Allozyme polymorphisms within and among open-pollinated and adapted exotic populations of maize
SummaryTwelve U.S. Corn Belt open-pollinated and five adapted exotic populations of maize (Zea mays L.) were assayed for allozyme… 
Highly Cited
1973
Highly Cited
1973
The complete amino acid sequence of cytoplasmic aspartate aminotransferase from pig heart
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