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Phomopsterones A and B, Two Functionalized Ergostane-Type Steroids from the Endophytic Fungus Phomopsis sp. TJ507A.
Two new functionalized ergostane-type steroids, phomopsterones A (1) and B (2), were isolated from the plant-derived Phomopsis sp. TJ507A. Their structures were determined on the basis of
Filicinic Acid Based Meroterpenoids with Anti-Epstein-Barr Virus Activities from Hypericum japonicum.
TLDR
Seven filicinic acid-based meroterpenoids, possessing 6/6/11, 6-6/7/5, or 6/ 6/10 ring systems, were isolated from Hypericum japonicum and exhibited significant efficacy on anti-Epstein-Barr virus and well accommodated to the binding pocket of 2GV9 predicted by the molecular docking.
Structure based discovery of clomifene as a potent inhibitor of cancer-associated mutant IDH1
TLDR
Clomifene may have clinical potential in tumor therapies as a safe and effective inhibitor of mutant IDH1 by virtual screening method and in vivo studies indicated that clomifenes significantly suppressed the tumor growth of HT1080-bearing CB-17/Icr-scid mice.
Fungal naphtho-γ-pyrones: Potent antibiotics for drug-resistant microbial pathogens
TLDR
This work is the first report of anti-drug-resistant bacterial activities of naphtho-γ-pyrones 1–8 and their possible antibacterial mechanism of action and provides an example of the successful application of in silico methods for drug target identification and validation and the identification of new lead antibiotic compounds against drug-resistant pathogens.
[Genetic variation, correlation and principle component analysis on morphological characteristics of various germplasm from Prunella vulgaris].
TLDR
The strong growth potential, the number of spica per plant and spica length were main factors for the selection of high yield breeding of P. vulgaris.
Fusicoccane-Derived Diterpenoids from Alternaria brassicicola: Investigation of the Structure-Stability Relationship and Discovery of an IKKβ Inhibitor.
The structure-stability relationships of 1-6 were investigated to show that 1 converted to 5 via a kinetic, solution-mediated autoxidation. In addition, alterbrassicene A (7), a fusicoccane-derived
Spiroaspertrione A, a Bridged Spirocyclic Meroterpenoid, as a Potent Potentiator of Oxacillin against Methicillin-Resistant Staphylococcus aureus from Aspergillus sp. TJ23.
Bioassay-guided isolation of cultures of Aspergillus sp. TJ23 yielded a novel terpene-polyketide hybrid spiromeroterpenoid, spiroaspertrione A (1), bearing a unique
Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2
TLDR
Benserazide (Benz), was identified as a selective HK2 inhibitor, could specifically bind to HK2 and significantly inhibit HK2 enzymatic activity in vitro, which provides a new direction for the development of Benz and its analogues as novel antitumor agents for cancer therapy.
Terreuspyridine: An Unexpected Pyridine-Fused Meroterpenoid Alkaloid with a Tetracyclic 6/6/6/6 Skeleton from Aspergillus terreus.
Terreuspyridine (1), the first 3,5-demethylorsellinic acid (DMOA) derived meroterpenoid alkaloid, was isolated from the fungus Aspergillus terreus, which represents a new type of meroterpenoid
Alterbrassicicene A, a Highly Transformed Fusicoccane-Derived Diterpenoid with Potent PPAR-γ Agonistic Activity from Alternaria brassicicola.
TLDR
Alterbrassicicene A, a fusicoccane-derived diterpenoid with an unprecedented framework, together with two known biosynthetic intermediates, were characterized from Alternaria brassicicola by extensive spectroscopic analyses and quantum chemical calculations.
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