Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism

@article{Sun2019AspulvinoneOA,
  title={Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism},
  author={Weiguang Sun and Shanshan Luan and Changxing Qi and Qingyi Tong and Shan Yan and Hua Li and Yonghui Zhang},
  journal={Cell Communication and Signaling : CCS},
  year={2019},
  volume={17}
}
BackgroundDistinctive from their normal counterparts, cancer cells exhibit unique metabolic dependencies on glutamine to fuel anabolic processes. Specifically, pancreatic ductal adenocarcinoma (PDAC) cells rely on an unconventional metabolic pathway catalyzed by aspartate transaminase 1 (GOT1) to rewire glutamine metabolism and support nicotinamide adenine dinucleotide phosphate (NADPH) production. Thus, the important role of GOT1 in energy metabolism and Reactive Oxygen Species (ROS) balance… 
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