Cytochrome p450 CYP2C9 enzyme

Known as: Cytochrome P450 PB-1, Cytochrome P450 MP 4, Cytochrome P 450 CYP2C9 
A cytochrome P-450 subtype that has specificity for acidic XENOBIOTICS. It oxidizes a broad range of important clinical drugs that fall under the… (More)
National Institutes of Health

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Papers overview

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2012
2012
Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines.
Compared with rodents and many other animal species, the human cytochrome P450 (P450) Cyp2c gene cluster varies significantly in… (More)
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2012
2012
Allele and genotype frequencies of the polymorphic cytochrome P450 genes (CYP1A1, CYP3A4, CYP3A5, CYP2C9 and CYP2C19) in the Jordanian population
Drug metabolizing enzymes participate in the neutralizing of xenobiotics and biotransformation of drugs. Human cytochrome P450… (More)
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Highly Cited
2011
Highly Cited
2011
Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice.
Cytochrome P-450 (CYP)-derived epoxyeicosatrienoic acids (EETs) possess potent anti-inflammatory effects in vitro. However, the… (More)
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Review
2009
Review
2009
Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development.
Cytochrome P450 2C9 (CYP2C9) is one of the most abundant CYP enzymes in the human liver. CYP2C9 metabolizes more than 100… (More)
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Highly Cited
2007
Highly Cited
2007
Genetic susceptibility to nonsteroidal anti-inflammatory drug-related gastroduodenal bleeding: role of cytochrome P450 2C9 polymorphisms.
BACKGROUND AND AIMS Several nonsteroidal anti-inflammatory drugs (NSAIDs) are metabolized by the cytochrome P450 2C9 (CYP2C9… (More)
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Review
2005
Review
2005
Clinical and toxicological relevance of CYP2C9: drug-drug interactions and pharmacogenetics.
CYP2C9 is a major cytochrome P450 enzyme that is involved in the metabolic clearance of a wide variety of therapeutic agents… (More)
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Highly Cited
2004
Highly Cited
2004
Discovery of new potentially defective alleles of human CYP2C9.
CYP2C9 is a clinically important enzyme, responsible for the metabolism of numerous clinically important therapeutic drugs. In… (More)
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2001
2001
Role of CYP2C9 polymorphism in losartan oxidation.
Losartan, an angiotensin II receptor antagonist, is oxidized by hepatic cytochromes P450 to an active carboxylic acid metabolite… (More)
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Highly Cited
1999
Highly Cited
1999
P-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies.
Many P-glycoprotein (P-gp) inhibitors studied in vitro and in vivo are also known or suspected to be substrates and/or inhibitors… (More)
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Review
1997
Review
1997
The cytochrome P450 4 (CYP4) family.
1. The CYP4 family consists of 11 subfamilies (CYP4A-CYP4M), which encode constitutive and inducible isozymes expressed in both… (More)
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