Cytochrome p450 CYP2C9 enzyme

Known as: Cytochrome P450 PB-1, Cytochrome P450 MP 4, Cytochrome P 450 CYP2C9 
A cytochrome P-450 subtype that has specificity for acidic XENOBIOTICS. It oxidizes a broad range of important clinical drugs that fall under the… (More)
National Institutes of Health

Papers overview

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2012
2012
Compared with rodents and many other animal species, the human cytochrome P450 (P450) Cyp2c gene cluster varies significantly in… (More)
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2012
2012
Drug metabolizing enzymes participate in the neutralizing of xenobiotics and biotransformation of drugs. Human cytochrome P450… (More)
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Highly Cited
2011
Highly Cited
2011
Cytochrome P-450 (CYP)-derived epoxyeicosatrienoic acids (EETs) possess potent anti-inflammatory effects in vitro. However, the… (More)
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Review
2009
Review
2009
Cytochrome P450 2C9 (CYP2C9) is one of the most abundant CYP enzymes in the human liver. CYP2C9 metabolizes more than 100… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND AND AIMS Several nonsteroidal anti-inflammatory drugs (NSAIDs) are metabolized by the cytochrome P450 2C9 (CYP2C9… (More)
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Review
2005
Review
2005
CYP2C9 is a major cytochrome P450 enzyme that is involved in the metabolic clearance of a wide variety of therapeutic agents… (More)
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Highly Cited
2004
Highly Cited
2004
CYP2C9 is a clinically important enzyme, responsible for the metabolism of numerous clinically important therapeutic drugs. In… (More)
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2001
2001
Losartan, an angiotensin II receptor antagonist, is oxidized by hepatic cytochromes P450 to an active carboxylic acid metabolite… (More)
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Highly Cited
1999
Highly Cited
1999
Many P-glycoprotein (P-gp) inhibitors studied in vitro and in vivo are also known or suspected to be substrates and/or inhibitors… (More)
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Review
1997
Review
1997
1. The CYP4 family consists of 11 subfamilies (CYP4A-CYP4M), which encode constitutive and inducible isozymes expressed in both… (More)
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