• Publications
  • Influence
Interferon Therapy Reduces the Risk for Hepatocellular Carcinoma: National Surveillance Program of Cirrhotic and Noncirrhotic Patients with Chronic Hepatitis C in Japan
An analysis of the effect of interferon therapy on the incidence and prevention of hepatocellular carcinoma in patients with chronic hepatitis C who have undergone liver biopsy at one of eight participating institutions supported by the Japan Ministry of Health and Welfare. Expand
Daclatasvir Plus Asunaprevir for Chronic HCV Genotype 1b Infection
Interferon‐free, ribavirin‐free all‐oral therapy with daclatasvir and asunaprevir for 24 weeks is well tolerated and can achieve a high rate of SVR in patients with HCV genotype 1b who were ineligible, intolerant, or had not responded to prior interferon-based therapy. Expand
Histologic Improvement of Fibrosis in Patients with Hepatitis C Who Have Sustained Response to Interferon Therapy
WhetherInterferon therapy was associated with regression of histologic fibrosis in 593 patients, a subset of whom received interferon, by using paired biopsy samples obtained 1 to 10 years apart is examined. Expand
Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial.
Curcumin seems to be a promising and safe medication for maintaining remission in patients with quiescent UC, and improved both CAI and EI, thus suppressing the morbidity associated with UC. Expand
Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: an implication for the antitumor potential of flavonoids.
In this study, we have investigated the underlying molecular mechanism for the potent proapoptotic effect of luteolin on human hepatoma cells both in vitro and in vivo, focusing on the signalExpand
Clearance of HCV Improves Insulin Resistance, Beta-Cell Function, and Hepatic Expression of Insulin Receptor Substrate 1 and 2
It was shown that clearance of HCV improves insulin resistance, beta-cell function, and hepatic IRS1/2 expression, as well as homeostasis model assessment method assessment method. Expand
Expression and Role of Vascular Endothelial Growth Factor in Liver Regeneration After Partial Hepatectomy in Rats
The results suggest that VEGF promotes proliferation of hepatocytes through reconstruction of liver sinusoids by proliferation of sinusoidal endothelial cells, which point to a new therapeutic strategy, the use of V EGF and other hepatocyte growth factors in fulminant or severe acute hepatitis. Expand
Helicobacter pylori in the natural environment.
Findings suggest the existence of H. pylori in the natural environment and a possible transmission route and nucleotide sequences of the samples amplified by PCR were highly homologous with each other. Expand
Expression of cyclooxygenase‐2 in human hepatocellular carcinoma: Relevance to tumor dedifferentiation
The present study is the first to demonstrate a high expression of COX‐2 in well‐differentiated HCC and a low expression in advanced HCC, in contrast to its continuous expression during colorectal carcinogenesis. Expand
Microvascular Invasion in Patients with Hepatocellular Carcinoma and Its Predictable Clinicopathological Factors
The presence of MVI was the most important risk factor affecting recurrence and survival in HCC patients after curative resection, and this study showed that gross classification of HCC can be very helpful in predicting the presence ofMVI. Expand