FAQ

Cytochrome P-450 CYP2B1

Known as: BROD, Benzyloxyresorufin O Dealkylase, CYP2B1 
A major cytochrome P-450 enzyme which is inducible by PHENOBARBITAL in both the LIVER and SMALL INTESTINE. It is active in the metabolism of… (More)

Topic mentions per year

Topic mentions per year

1977-2017
020406019772017

Related topics

Related topics

12 relations

Broader (3)

Cytochrome P450OxidoreductaseSteroid Hydroxylases
In BloodProcess of secretionadministration & dosageantagonists & inhibitors
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Cytochrome P-450 CYP2B1
Oxidoreductase
physiological aspects
Cytochrome P450
chemical synthesis
Steroid Hydroxylases

Papers overview

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Highly Cited
2004
Highly Cited
2004
Assessment of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture, in the EDSP male and female pubertal protocols.
DE-71, a commercial mixture, was used to test the sensitivity of the female and male pubertal protocol to detect thyroid active… (More)
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Highly Cited
2002
Highly Cited
2002
Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption.
The objective of the current study was to characterize the effects of DE-71 (a commercial polybrominated diphenyl ether mixture… (More)
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Highly Cited
2001
Highly Cited
2001
The role of Drosophila CID in kinetochore formation, cell-cycle progression and heterochromatin interactions
Centromere function requires the coordination of many processes including kinetochore assembly, sister chromatid cohesion… (More)
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Highly Cited
2001
Highly Cited
2001
Effects of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) on thyroid hormone and vitamin A levels in rats and mice
The ability of the commercial polybrominated diphenyl ether (PBDE) preparation Bromkal 70-5 DE to alter thyroid hormone and… (More)
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Highly Cited
2001
Highly Cited
2001
Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats.
Polybrominated diphenyl ethers (PBDEs), used as flame retardants, are ubiquitous environmental contaminants. PBDEs act as… (More)
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Highly Cited
1998
Highly Cited
1998
An oncolytic viral mutant that delivers the CYP2B1 transgene and augments cyclophosphamide chemotherapy
Herpes simplex viruses type 1 (HSV-1) with an inactivated viral ribonucleotide reductase (Hsrr, ICP6) were designed to target… (More)
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Highly Cited
1997
Highly Cited
1997
Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation.
The level of expression and interindividual variation in human hepatic microsomal cytochrome P450 (CYP) 2B6 was characterized… (More)
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1995
1995
Intratumoral activation and enhanced chemotherapeutic effect of oxazaphosphorines following cytochrome P-450 gene transfer: development of a combined chemotherapy/cancer gene therapy strategy.
Cyclophosphamide and its isomer ifosfamide are cell cycle-nonspecific alkylating agents that undergo bioactivation catalyzed by… (More)
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Highly Cited
1994
Highly Cited
1994
Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver.
The O-dealkylations of ethoxyresorufin and pentoxyresorufin are widely used activity probes for measuring the cytochrome P450… (More)
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1993
1993
Regional distribution and expression modulation of cytochrome P-450 and epoxide hydrolase mRNAs in the rat brain.
In the present study, we developed a very sensitive, semiquantitative assay based on the reverse transcriptase-coupled polymerase… (More)
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