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Cystine/Glutamate Transporter Protein

Known as: System Xc(-) Transporter-Related Protein, Amino Acid Transport System xc-, XCT 
Cystine/glutamate transporter protein (501aa, ~55 kDa) is encoded by the human SLC7A11 gene. This protein is involved in the exchange of anionic… 
National Institutes of Health

Related topics

Related topics

14 relations
Amino Acid TransporterCellular MembraneIntegral Membrane ProteinsIntracellular Transport

Papers overview

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2020
2020
RAS-driven oncogenesis is supported by downstream antioxidant programs
ABSTRACT In our recent study, we demonstrated that oncogenic RAS (rat sarcoma)-mediated transformation and tumorigenesis are… 
2017
2017
Effects of repeated cocaine exposure and withdrawal on voluntary ethanol drinking, and the expression of glial glutamate transporters in mesocorticolimbic system of P rats
2017
2017
Discovery and Mechanistic Elucidation of a Class of PDI Inhibitors for the Treatment of Glioblastoma
Protein disulfide isomerase (PDI) is overexpressed in glioblastoma, the most aggressive form of brain cancer, and folds nascent… 
2010
2010
Prognostic significance of xCT gene single nucleotide polymorphisms (SNPs) in patients (pts) with advanced pancreatic cancer (PC) treated with gemcitabine (GEM) plus platinum analogues (PLAT).
4065 Background: The plasma membrane xc- cystine/glutamate transporter mediates cellular uptake of cystine in exchange for… 
2010
2010
Overexpression of xCT induces up-regulation of 14-3-3β in Kaposi's sarcoma
KSHV (Kaposi's sarcoma-associated herpesvirus), or HHV-8 (human herpesvirus 8), is associated with the pathogenesis of KS, the… 
2009
2009
Burn injury induces the expression of cystine/glutamate transporter (x(c)(-)) in mouse T cells.
2008
2008
Deficiency of the cystine-transporter gene, xCT, does not exacerbate the deleterious phenotypic consequences of SOD1 knockout in mice
Because glutathione scavenges reactive oxygen species (ROS) and also donates electrons to antioxidative systems, it may… 
2006
2006
Transcription regulation in NIH3T3 cell clones resistant to diethylmaleate-induced oxidative stress and apoptosis.
To investigate the molecular mechanisms underlying the induction of cell resistance to oxidative stress, NIH3T3 cell clones (NIH… 
2004
2004
Geometrical accuracy and fusion of multimodal vascular images: a phantom study.
The aim of this work was to compare the geometrical accuracy of x-ray angiography, magnetic resonance imaging (MRI), x-ray… 
1995
1995
A role for gamma‐glutamyl transpeptidase and the amino acid transport system xc‐ in cystine transport by a human pancreatic duct cell line.
1. The roles of the gamma‐glutamyl cycle and the anionic amino acid transport system xc‐ in mediating L‐cystine uptake were… 
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