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Fundamental roles of reactive oxygen species and protective mechanisms in the female reproductive system
TLDR
While anti-oxidative enzymes, such as superoxide dismutase and peroxidase, play a central role in eliminating oxidative stress, reduction-oxidation (redox) systems, comprised of mainly glutathione and thioredoxin, function to reduce the levels of oxidized molecules.
Peroxiredoxin 4 knockout results in elevated spermatogenic cell death via oxidative stress.
TLDR
The results suggest that the presence of Prx4, most likely the membrane-bound form, is important for spermatogenesis, but not an absolute requisite.
Cooperative function of antioxidant and redox systems against oxidative stress in male reproductive tissues.
TLDR
This work overviews the current understanding of the cooperative function of antioxidative and redox systems that are involved in male fertility and suggests that a comprehensive understanding will be required to maintain the physiological functions of male reproductive system.
Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production.
TLDR
Evidence is presented to show that SOD1 is primarily required for maintaining erythrocyte lifespan by suppressing oxidative stress, and that the intake of antioxidants would prevent certain autoimmune responses by maintaining an appropriate redox balance in ERYthrocytes.
B- to plasma-cell terminal differentiation entails oxidative stress and profound reshaping of the antioxidant responses.
TLDR
It is suggested that the early intracellular production of H( 2)O(2) facilitates B-cell proliferation and reveal a role for the Nrf2 pathway in the differentiation and function of IgM-secreting cells.
Possible involvement of the membrane-bound form of peroxiredoxin 4 in acrosome formation during spermiogenesis of rats.
TLDR
The conversion of the soluble form to the membrane-bound form may have a role in the acrosome formation during vesicular reorganization during spermiogenesis in rats.
In Vivo Study on Cross Talk between Inducible Nitric-Oxide Synthase and Cyclooxygenase in Rat Gastric Mucosa: Effect of Cyclooxygenase Activity on Nitric Oxide Production
TLDR
It is demonstrated that in the LPS-treated rat gastric mucosa, PGE2 enhances the release of NO after activation of iNOS, although NO produced byiNOS does not stimulate therelease of PGE 2 by COXs.
Accelerated impairment of spermatogenic cells in sod1-knockout mice under heat stress
TLDR
Data suggest that ROS are generated during heat stress and cause spermatogenic cell death, and generated ROS may function as a type of signal for cell death rather than directly causing oxidative damage to cells.
The expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis.
TLDR
The results herein suggest that the GR system in Sertoli cells is involved in the supplementation of GSH to spermatogenic cells in which high levels of cysteine are required for protamine synthesis.
Prevention of inflammation-mediated acquisition of metastatic properties of benign mouse fibrosarcoma cells by administration of an orally available superoxide dismutase
TLDR
It is suggested that the orally active SOD derivative prevented tumour progression promoted by inflammation, which is thought to be through scavenging inflammatory cell-derived superoxide anion.
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