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Cyclotides

Known as: Cyclotides [Chemical/Ingredient] 
A continuous circle of peptide bonds, typically of 2-3 dozen AMINO ACIDS, so there is no free N- or C-terminus. They are further characterized by six… 
National Institutes of Health

Related topics

Related topics

30 relations

Broader (1)

Cyclic Peptides
In BloodProcess of secretionagonistsantagonists & inhibitors

Narrower (21)

MCoTI-I protein, Momordica cochinchinensisMCoTI-III protein, Momordica cochinchinensisPMP-C peptide, insectPMP-D2 peptide, insect

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Discovery, structure, function, and applications of cyclotides: circular proteins from plants.
Cyclotides are plant-derived cyclic peptides that have a head-to-tail cyclic backbone and three conserved disulphide bonds that… 
Highly Cited
2011
Highly Cited
2011
Discovery of cyclotides in the fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins.
Cyclotides are plant proteins whose defining structural features are a head-to-tail cyclized backbone and three interlocking… 
Highly Cited
2010
Highly Cited
2010
Anticancer and chemosensitizing abilities of cycloviolacin 02 from Viola odorata and psyle cyclotides from Psychotria leptothyrsa.
Cycloviolacin O2 (CyO2), a cyclotide from Viola odorata (Violaceae) has antitumor effects and causes cell death by membrane… 
Highly Cited
2008
Highly Cited
2008
Plant cyclotides disrupt epithelial cells in the midgut of lepidopteran larvae
Several members of the Rubiaceae and Violaceae plant families produce a series of cyclotides or macrocyclic peptides of 28–37 aa… 
Review
2008
Review
2008
Cyclotides as natural anti‐HIV agents
Cyclotides are disulfide rich macrocyclic plant peptides that are defined by their unique topology in which a head‐to‐tail… 
Highly Cited
2008
Highly Cited
2008
Alanine Scanning Mutagenesis of the Prototypic Cyclotide Reveals a Cluster of Residues Essential for Bioactivity*
The cyclotides are stable plant-derived mini-proteins with a topologically circular peptide backbone and a knotted arrangement of… 
Highly Cited
2007
Highly Cited
2007
Mechanism of action of cytotoxic cyclotides: cycloviolacin O2 disrupts lipid membranes.
In recent years, the cyclotides have emerged as the largest family of naturally cyclized proteins. Cyclotides display potent… 
Highly Cited
2002
Highly Cited
2002
Cyclotides: a novel type of cytotoxic agents.
Cytotoxic activities of three naturally occurring macrocyclic peptides (cyclotides) isolated from the two violets, Viola arvensis… 
Review
2002
Review
2002
Circular proteins--no end in sight.
Review
2002
Review
2002
The cyclotides: novel macrocyclic peptides as scaffolds in drug design.
Cyclotides are a novel class of circular, disulfide-rich peptides (approximately 30 amino acids) that display a broad range of… 
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