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Cycloheximide

Known as: 2,6-Piperidinedione, 4-(2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-, (1S-(1alpha(S*),3alpha,5beta))-, Cicloheximide, Cycloheximide [Chemical/Ingredient] 
Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Although the protein synthesis inhibitor cycloheximide (CHX) has been known for decades, its precise mechanism of action remains… Expand
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Highly Cited
2001
Highly Cited
2001
ABSTRACT The caspase 8 homologue FLICE-inhibitory protein (cFLIP) is a potent negative regulator of death receptor-induced… Expand
Highly Cited
1994
Highly Cited
1994
THE mitogen-activated protein (MAP) kinases Erk-1 and Erk-2 are proline-directed kinases that are themselves activated through… Expand
Highly Cited
1994
Highly Cited
1994
The promoter of the murine gene encoding inducible nitric oxide synthase (iNOS) contains an NF-kappa B site beginning 55 base… Expand
Highly Cited
1992
Highly Cited
1992
We have identified a 50-nucleotide enhancer from the human erythropoietin gene 3'-flanking sequence which can mediate a sevenfold… Expand
Highly Cited
1991
Highly Cited
1991
Corticosteroids, calcium ionophores and anti-CD3 monoclonal antibodies kill mouse thymocytes incubated in vitro. Cell death is… Expand
Highly Cited
1991
Highly Cited
1991
Hydrogen peroxide and oxygen radicals are agents commonly produced during inflammatory processes. In this study, we show that… Expand
Highly Cited
1986
Highly Cited
1986
The mRNAs of transiently expressed genes frequently contain an AU-rich sequence in the 3' untranslated region. We introduced a 51… Expand
Highly Cited
1983
Highly Cited
1983
We show that c-myc is an inducible gene that is regulated by specific growth signals in a cell-cycle-dependent manner… Expand
Highly Cited
1971
Highly Cited
1971
Abstract Cycloheximide and related glutarimide antibiotics have been shown to affect binding, transfer enzyme II-dependent… Expand
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