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Although the protein synthesis inhibitor cycloheximide (CHX) has been known for decades, its precise mechanism of action remains… Expand ABSTRACT The caspase 8 homologue FLICE-inhibitory protein (cFLIP) is a potent negative regulator of death receptor-induced… Expand THE mitogen-activated protein (MAP) kinases Erk-1 and Erk-2 are proline-directed kinases that are themselves activated through… Expand The promoter of the murine gene encoding inducible nitric oxide synthase (iNOS) contains an NF-kappa B site beginning 55 base… Expand We have identified a 50-nucleotide enhancer from the human erythropoietin gene 3'-flanking sequence which can mediate a sevenfold… Expand Corticosteroids, calcium ionophores and anti-CD3 monoclonal antibodies kill mouse thymocytes incubated in vitro. Cell death is… Expand Hydrogen peroxide and oxygen radicals are agents commonly produced during inflammatory processes. In this study, we show that… Expand The mRNAs of transiently expressed genes frequently contain an AU-rich sequence in the 3' untranslated region. We introduced a 51… Expand We show that c-myc is an inducible gene that is regulated by specific growth signals in a cell-cycle-dependent manner… Expand Abstract Cycloheximide and related glutarimide antibiotics have been shown to affect binding, transfer enzyme II-dependent… Expand