Cycloheximide

Known as: 2,6-Piperidinedione, 4-(2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-, (1S-(1alpha(S*),3alpha,5beta))-, Cicloheximide, Cycloheximide [Chemical/Ingredient] 
Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.

Topic mentions per year

Topic mentions per year

1952-2017
020040060019522016

Papers overview

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Highly Cited
2010
Highly Cited
2010
Although the protein synthesis inhibitor cycloheximide (CHX) has been known for decades, its precise mechanism of action remains… (More)
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Highly Cited
2001
Highly Cited
2001
The caspase 8 homologue FLICE-inhibitory protein (cFLIP) is a potent negative regulator of death receptor-induced apoptosis. We… (More)
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Highly Cited
2000
Highly Cited
2000
Malfolded proteins in the endoplasmic reticulum (ER) inhibit translation initiation. This response is believed to be mediated by… (More)
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Highly Cited
2000
Highly Cited
2000
Bitter taste perception provides animals with critical protection against ingestion of poisonous compounds. In the accompanying… (More)
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Highly Cited
1994
Highly Cited
1994
The mitogen-activated protein (MAP) kinases Erk-1 and Erk-2 are proline-directed kinases that are themselves activated through… (More)
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Highly Cited
1993
Highly Cited
1993
Apoptosis is a morphologically and biochemically distinct form of cell death that occurs under a variety of physiological and… (More)
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Highly Cited
1991
Highly Cited
1991
Corticosteroids, calcium ionophores and anti-CD3 monoclonal antibodies kill mouse thymocytes incubated in vitro. Cell death is… (More)
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Highly Cited
1991
Highly Cited
1991
Hydrogen peroxide and oxygen radicals are agents commonly produced during inflammatory processes. In this study, we show that… (More)
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Highly Cited
1986
Highly Cited
1986
The mRNAs of transiently expressed genes frequently contain an AU-rich sequence in the 3' untranslated region. We introduced a 51… (More)
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Highly Cited
1971
Highly Cited
1971
Cycloheximide and related glutarimide antibiotics have been shown to affect binding, transfer enzyme II-dependent movement, and… (More)
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