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Cycloheximide

Known as: 2,6-Piperidinedione, 4-(2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-, (1S-(1alpha(S*),3alpha,5beta))-, Cicloheximide, Cycloheximide [Chemical/Ingredient] 
Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.
National Institutes of Health

Papers overview

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Review
2016
Review
2016
The oral route is a preferred method of drug administration, though achieving effective drug delivery and minimizing off-target… Expand
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Highly Cited
2012
Highly Cited
2012
Chapter 1 • Distribution of a variable tells the values a variable attained and how often. • Describe a distribution of a… Expand
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Highly Cited
2010
Highly Cited
2010
Although the protein synthesis inhibitor cycloheximide (CHX) has been known for decades, its precise mechanism of action remains… Expand
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Highly Cited
2001
Highly Cited
2001
The caspase 8 homologue FLICE-inhibitory protein (cFLIP) is a potent negative regulator of death receptor-induced apoptosis. We… Expand
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Highly Cited
2000
Highly Cited
2000
Malfolded proteins in the endoplasmic reticulum (ER) inhibit translation initiation. This response is believed to be mediated by… Expand
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Highly Cited
1993
Highly Cited
1993
Apoptosis is a morphologically and biochemically distinct form of cell death that occurs under a variety of physiological and… Expand
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Highly Cited
1992
Highly Cited
1992
We have identified a 50-nucleotide enhancer from the human erythropoietin gene 3'-flanking sequence which can mediate a sevenfold… Expand
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Highly Cited
1991
Highly Cited
1991
Corticosteroids, calcium ionophores and anti-CD3 monoclonal antibodies kill mouse thymocytes incubated in vitro. Cell death is… Expand
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Highly Cited
1991
Highly Cited
1991
Hydrogen peroxide and oxygen radicals are agents commonly produced during inflammatory processes. In this study, we show that… Expand
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Highly Cited
1986
Highly Cited
1986
The mRNAs of transiently expressed genes frequently contain an AU-rich sequence in the 3' untranslated region. We introduced a 51… Expand
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