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Cyclin D2

Known as: Cyclin D2 [Chemical/Ingredient] 
A cyclin D subtype which is regulated by GATA4 TRANSCRIPTION FACTOR. Experiments using KNOCKOUT MICE suggest a role for cyclin D2 in granulosa cell… 
National Institutes of Health

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CCND2 geneIn BloodProcess of secretionagonists

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CCND2 protein, human

Papers overview

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2014
2014
Cyclin D2 is a GATA4 cofactor in cardiogenesis
Significance Cyclin D2 is a cell cycle regulator with spatially restricted expression. Loss and gain of function in animal models… 
2009
2009
A splice variant of cyclin D2 regulates cardiomyocyte cell cycle through a novel protein aggregation pathway
The mammalian heart lacks intrinsic ability to replace diseased myocardium with newly divided myocytes. There is scant… 
Review
2007
Review
2007
PTEN, a general negative regulator of cyclin D expression
The tumor-suppressor phosphatase with tensin homology (PTEN) is frequently mutated in many malignancies and is one of the most… 
Highly Cited
2004
Highly Cited
2004
A Permissive Role for Phosphatidylinositol 3-Kinase in the Stat5- mediated Expression of Cyclin D2 by the Interleukin-2 Receptor*
The interleukin-2 (IL-2) receptor promotes T cell proliferation in part by inducing the expression of D-type cyclins, which… 
2004
2004
Proliferation profile of classical Hodgkin's lymphomas. Increased expression of the protein cyclin D2 in Hodgkin's and Reed–Sternberg cells
There is accumulating evidence that Hodgkin's and Reed–Sternberg cells of classical Hodgkin's lymphomas (cHL) display multiple… 
2004
2004
Enforced expression of cyclin D2 enhances the proliferative potential of myeloid progenitors, accelerates in vivo myeloid reconstitution, and promotes rescue of mice from lethal myeloablation.
Severe and prolonged cytopenias represent a considerable problem in clinical stem cell transplantations. Cytokine-induced ex vivo… 
2003
2003
Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells.
Signal transducer and activator of transcription 5 (STAT5) activation plays a central role in GH- and prolactin-mediated signal… 
2003
2003
Cyclin D2 and p27 are tissue-specific regulators of tumorigenesis in inhibin alpha knockout mice.
Inhibins are heterodimeric (alpha:betaA and alpha:betaB) endocrine, paracrine, and autocrine factors of the TGFbeta superfamily… 
Highly Cited
1999
Highly Cited
1999
Early Induction of Cyclin D2 Expression in Phorbol Ester–responsive B-1 Lymphocytes
B-1 lymphocytes represent a distinct B cell subset with characteristic features that include self-renewing capacity and unusual… 
1998
1998
Cyclin D2 Interacts with cdk‐5 and Modulates Cellular cdk‐5/p35 Activity
Abstract: Cyclin‐dependent kinase‐5 (cdk‐5) is a serine/threonine kinase that displays neurone‐specific activity. Experimental… 
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