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Cyclin A1

Known as: Cyclin A1 [Chemical/Ingredient], Cyclin-A1 
Cyclin-A1 (465 aa, ~52 kDa) is encoded by the human CCNA1 gene. This protein is involved in the G1/S and G2/M cell cycle transitions.
National Institutes of Health

Related topics

Related topics

14 relations
CCNA1 geneCell Cycle ControlCell NucleusGenes, Regulator

Papers overview

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Highly Cited
2006
Highly Cited
2006
Promoter methylation of P16, RARβ, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing
Methylation profiling of cancer tissues has identified this mechanism as an important component of carcinogenesis. Epigenetic… 
Highly Cited
2005
Highly Cited
2005
Cyclin A1, the alternative A-type cyclin, contributes to G1/S cell cycle progression in somatic cells
Cyclin A1 is an alternative A-type cyclin that is essential for spermatogenesis, but it is also expressed in hematopoietic… 
Highly Cited
2004
Highly Cited
2004
Inverse Correlation between Cyclin A1 Hypermethylation and p53 Mutation in Head and Neck Cancer Identified by Reversal of Epigenetic Silencing
Aberrant promoter hypermethylation of tumor suppressor genes is proposed to be a common feature of primary cancer cells. We… 
Highly Cited
2004
Highly Cited
2004
The Cyclin A1-CDK2 Complex Regulates DNA Double-Strand Break Repair
ABSTRACT Vertebrates express two A-type cyclins; both associate with and activate the CDK2 protein kinase. Cyclin A1 is required… 
Highly Cited
2001
Highly Cited
2001
Cyclin E is the only cyclin-dependent kinase 2-associated cyclin that predicts metastasis and survival in early stage non-small cell lung cancer.
Progression through G1-S transition and S phase of the cell cycle is mediated by cyclin-dependent kinase 2 (cdk2), which… 
Highly Cited
1999
Highly Cited
1999
Cyclin A1 expression in leukemia and normal hematopoietic cells.
Human cyclin A1 is a newly cloned, tissue-specific cyclin that is prominently expressed in normal testis. In this study, we… 
Highly Cited
1999
Highly Cited
1999
c-myb transactivates the human cyclin A1 promoter and induces cyclin A1 gene expression.
Cyclin A1 differs from other cyclins in its highly restricted expression pattern. Besides its expression during spermatogenesis… 
Highly Cited
1997
Highly Cited
1997
Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines.
In this study, we isolated and characterized a human cyclin A-like gene that we named cyclin A1. Cyclin A1 has 48% identity with… 
Highly Cited
1997
Highly Cited
1997
Ionizing radiation induces apoptosis and elevates cyclin A1-Cdk2 activity before but not after the midblastula transition in Xenopus.
After the twelfth cell division in Xenopus embryos, zygotic gene transcription is activated, cells become motile, and cell… 
Highly Cited
1996
Highly Cited
1996
A distinct cyclin A is expressed in germ cells in the mouse.
In this paper, the existence of two A-type cyclins in the mouse is demonstrated. In the adult mouse, the expression of cyclin A1… 
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