Cyclic Nucleotide Phosphodiesterases, Type 2A

Known as: PDE2A, cGSPDE, cGMP-Dependent 3',5'-Cyclic Phosphodiesterase 
cGMP-dependent 3',5'-cyclic phosphodiesterase (941 aa, ~106 kDa) is encoded by the human PDE2A gene. This protein is involved in the catabolism of… (More)
National Institutes of Health

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Topic mentions per year

1994-2017
02419942017

Papers overview

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2017
2017
Phosphodiesterase 2A (PDE2A) inhibitors have been reported to demonstrate in vivo activity in preclinical models of cognition. To… (More)
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Review
2016
Review
2016
INTRODUCTION The cyclic nucleotides cAMP and cGMP are ubiquitous intracellular second messengers regulating a large variety of… (More)
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2015
2015
Elevated B-type natriuretic peptide (BNP) regulates cGMP-phosphodiesterase activity. Its elevation is regarded as an early… (More)
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2015
2015
OBJECTIVE To investigate the expression and distribution of phosphodiesterase (PDE) isoenzymes PDE1A, PDE2A, PDE4A, PDE4B, and… (More)
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2012
2012
The heart peptide hormone atrial natriuretic peptide (ANP) regulates blood pressure by stimulating guanylyl cyclase-A to produce… (More)
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2009
2009
We report here the generation and pharmacological characterization of a phosphodiesterase 2A (PDE2A) reporter cell line. Human… (More)
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Review
2004
Review
2004
Platelets contain two cyclic adenosine monophosphate (cAMP) phosphodiesterases (PDEs) that regulate the level of cAMP, the major… (More)
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2001
2001
PDE11A is a dual-substrate, cAMP and cGMP, cyclic nucleotide phosphodiesterase (PDE). Presently four unique variants carrying… (More)
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1999
1999
We developed selective monoclonal antibodies and used them for Western and immunocytochemical analyses to determine the tissue… (More)
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1994
1994
A cDNA clone for cyclic GMP Stimulated Phosphodiesterase (cGSPDE; PDE2) was isolated from a rat brain cDNA library. The cDNA has… (More)
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