Skip to search formSkip to main contentSkip to account menu

Cyclic Nucleotide Phosphodiesterases, Type 2A

Known as: PDE2A, cGSPDE, cGMP-Dependent 3',5'-Cyclic Phosphodiesterase 
cGMP-dependent 3',5'-cyclic phosphodiesterase (941 aa, ~106 kDa) is encoded by the human PDE2A gene. This protein is involved in the catabolism of… 
National Institutes of Health

Related topics

Related topics

10 relations

Broader (1)

Cyclic Nucleotide Phosphodiesterases, Type 2
Enzyme GeneEsterase GeneHydrolaseHydrolysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation
Highly Cited
2013
Highly Cited
2013
Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase A.
Highly Cited
2013
Highly Cited
2013
Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the development of a novel…
To accelerate the discovery of novel small molecule central nervous system (CNS) positron emission tomography (PET) ligands, we… 
2013
2013
Phosphodiesterase-2 inhibitor reverses corticosterone-induced neurotoxicity and related behavioural changes via cGMP/PKG dependent pathway.
Phosphodiesterase 2 (PDE2) is an enzyme responsible for hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine… 
Highly Cited
2009
Highly Cited
2009
Dual Acylation of PDE2A Splice Variant 3
The cGMP-stimulated PDE2A hydrolyzes both cyclic nucleotides, cGMP and cAMP. Three splice variants have been cloned from several… 
Highly Cited
2007
Highly Cited
2007
Phosphodiesterase 2A Forms a Complex with the Co-chaperone XAP2 and Regulates Nuclear Translocation of the Aryl Hydrocarbon Receptor*
Phosphodiesterase type 2A (PDE2A) hydrolyzes cyclic nucleotides cAMP and cGMP, thus efficiently controlling cNMP-dependent… 
Highly Cited
2004
Highly Cited
2004
Differentiation of human monocytes in vitro with granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor produces distinct changes in cGMP phosphodiesterase…
Review
2002
Review
2002
GAF domains: two-billion-year-old molecular switches that bind cyclic nucleotides.
GAF domains represent one of the largest families of small-molecule binding units present in nature. The first mammalian GAF… 
Highly Cited
1999
Highly Cited
1999
Differential Expression of the Cyclic GMP-stimulated Phosphodiesterase PDE2A in Human Venous and Capillary Endothelial Cells
We developed selective monoclonal antibodies and used them for Western and immunocytochemical analyses to determine the tissue… 
Highly Cited
1994
Highly Cited
1994
A novel cyclic GMP stimulated phosphodiesterase from rat brain.
A cDNA clone for cyclic GMP Stimulated Phosphodiesterase (cGSPDE; PDE2) was isolated from a rat brain cDNA library. The cDNA has… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)