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Cyclic Nucleotide Phosphodiesterases, Type 7

Known as: Phosphodiesterase 7, cAMP Phosphodiesterase-7, Phosphodiesterase-7 
A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC AMP. Several isoforms of the enzyme type exist, each with its own… 
National Institutes of Health

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In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease
Highly Cited
2013
Highly Cited
2013
Inhibition of endogenous phosphodiesterase 7 promotes oligodendrocyte precursor differentiation and survival
During the development of the central nervous system (CNS), oligodendrocyte precursors (OPCs) are generated in specific sites… 
Highly Cited
2012
Highly Cited
2012
Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model.
2012
2012
Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds.
Phosphodiesterase (PDE) 7 is involved in proinflammatory processes, being widely expressed both on lymphocytes and on certain… 
2012
2012
5-Imino-1,2-4-thiadiazoles and quinazolines derivatives as glycogen synthase kinase 3β (GSK-3β) and phosphodiesterase 7 (PDE7) inhibitors: determination of blood-brain barrier penetration and binding…
Review
2008
Review
2008
PDE7 inhibitors as new drugs for neurological and inflammatory disorders
Background: Phosphodiesterase 7 (PDE7) is a high affinity cAMP-specific PDE whose functional role in T cells has been the subject… 
Review
2005
Review
2005
Phosphodiesterase-4: selective and dual-specificity inhibitors for the therapy of chronic obstructive pulmonary disease.
  • M. Giembycz
  • Proceedings of the American Thoracic Society
  • 2005
  • Corpus ID: 23634887
Phosphodiesterase-4 isoenzymes have absolute specificity for cyclic adenosine-3',5'-monophosphate and are considered potential… 
Highly Cited
2004
Highly Cited
2004
Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a Selective Inhibitor of Phosphodiesterase 7: In Vitro Studies in Human Monocytes, Lung Macrophages, and CD8+ T-Lymphocytes
The biochemical and pharmacological characteristics in human proinflammatory cells of BRL 50481 [3-(N,N-dimethylsulfonamido)-4… 
Highly Cited
2002
Highly Cited
2002
Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors
Even though the existence of phosphodiesterase (PDE) 7 in T cells has been proved, the lack of a selective PDE7 inhibitor has… 
Highly Cited
1999
Highly Cited
1999
CD3- and CD28-dependent induction of PDE7 required for T cell activation.
Costimulation of both the CD3 and CD28 receptors is essential for T cell activation. Induction of adenosine 3',5'-monophosphate… 
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